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Titolo:
A NOVEL BASEMENT MEMBRANE-INDUCED GENE IDENTIFIED IN THE HUMAN ENDOMETRIAL ADENOCARCINOMA CELL-LINE HEC1B
Autore:
TREECK O; STRUNCK E; VOLLMER G;
Indirizzi:
MED UNIV LUBECK,INST MOL MED,RATZEBURGER ALLEE 160 D-23538 LUBECK GERMANY
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 425, anno: 1998,
pagine: 426 - 430
SICI:
0014-5793(1998)425:3<426:ANBMGI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR-MATRIX; TERMINAL DIFFERENTIATION; EPITHELIAL-CELLS; MESSENGER-RNA; EXPRESSION;
Keywords:
BASEMENT MEMBRANE; ENDOMETRIAL ADENOCARCINOMA; EXTRACELLULAR MATRIX; CELL-MATRIX INTERACTION; HEC1B CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
O. Treeck et al., "A NOVEL BASEMENT MEMBRANE-INDUCED GENE IDENTIFIED IN THE HUMAN ENDOMETRIAL ADENOCARCINOMA CELL-LINE HEC1B", FEBS letters, 425(3), 1998, pp. 426-430

Abstract

Cultured HEC1B human endometrial adenocarcinoma cells respond to reconstituted basement membrane (Matrigel) by morphological and functionaldifferentiation in vitro. Our goal is to identify genes involved in this differentiation process. By means of rt-PCR, we were able to isolate the novel 2.4 kb Matrigel-induced transcript icb-l containing an open reading frame predicting a 31.7 kDa protein, The time-dependent induction of icb-l gene expression by basement membrane,vas confirmed by Northern blot experiments. In a data bank search, several EST homologues corresponding to the 3' untranslated region could be found. In summary, icb-1 as a new tool enables us to study molecular mechanisms of cell-matrix interactions contributing to carcinogenesis. (C) 1998 Federation of European Biochemical Societies.

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Documento generato il 07/07/20 alle ore 04:59:47