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Titolo:
FLUMAZENIL REVERSES THE DECREASE IN THE HYPNOTIC ACTIVITY OF PENTOBARBITAL BY SOCIAL-ISOLATION STRESS - ARE ENDOGENOUS BENZODIAZEPINE RECEPTOR LIGANDS INVOLVED
Autore:
OJIMA K; MATSUMOTO K; WATANABE H;
Indirizzi:
TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU ORIENTAL MED,DEPT PHARMACOL,2630 SUGITAMI TOYAMA 93001 JAPAN TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU ORIENTAL MED,DEPT PHARMACOL TOYAMA 93001 JAPAN
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 745, anno: 1997,
pagine: 127 - 133
SICI:
0006-8993(1997)745:1-2<127:FRTDIT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIAZEPAM BINDING INHIBITOR; AGGRESSIVE-BEHAVIOR; CEREBRAL-CORTEX; GABA RECEPTOR; ISOLATED MICE; RAT-BRAIN; HIPPOCAMPUS; SYSTEMS; DBI;
Keywords:
SOCIAL ISOLATION STRESS; PENTOBARBITAL SLEEP; GABA(A)/BENZODIAZEPINE RECEPTOR COMPLEX; GABA-STIMULATED CL-36(-) UPTAKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
K. Ojima et al., "FLUMAZENIL REVERSES THE DECREASE IN THE HYPNOTIC ACTIVITY OF PENTOBARBITAL BY SOCIAL-ISOLATION STRESS - ARE ENDOGENOUS BENZODIAZEPINE RECEPTOR LIGANDS INVOLVED", Brain research, 745(1-2), 1997, pp. 127-133

Abstract

Long-term social isolation stress has been shown to cause a decrease in pentobarbital (PB)-induced sleeping time in mice. In the present study, to clarify whether the GABA(A)/benzodiazepine (BZD) receptor system is involved in the decrease in the hypnotic activity of PB by social isolation stress, we examined the effects of BZD receptor ligands onthe PB-induced sleep in group-housed and socially isolated mice. Moreover, we also tested whether social isolation stress affects the ability of GABA to stimulate Cl-36(-) uptake or the modulatory effect of diazepam and PB on GABA-induced stimulation of Cl-36(-) uptake into synaptoneurosomes prepared from mouse brain. Social isolation stress significantly decreased the PB-induced sleeping time in mice. The BZD receptor agonist diazepam (0.1-0.8 mg/kg, i.p.) dose-dependently prolonged PB sleep in group-housed and isolated mice, but the effect was weaker in isolated mice. In contrast, FG7142 (5-10 mg/kg, i.p.), a BZD receptor inverse agonist, shortened the sleep in group-housed but not in isolated mice. Flumazenil (16.5-33 nmol, i.c.v.), a selective BZD receptor antagonist, caused PB sleep in isolated mice to return to the level of group-housed mice, at the dose that antagonized the effects of diazepam and FG7142 on PB sleep in group-housed mice. However, this antagonist alone produced no effect on PB sleep in group-housed mice. Socialisolation stress decreased the ability of GABA (0.6-200 mu M) Io Stimulate Cl-36(-) uptake into synaptoneurosomes but this stress had no effect on PB- and diazepam-induced enhancement of GABA-stimulated Cl-36(-) uptake. These results suggest that endogenous substance(s) with an inverse BZD receptor agonist-like property and the changes in the ability of GABA to stimulate chloride ion channels are involved in the decrease in the hypnotic activity of pentobarbital following social isolation stress.

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Documento generato il 29/11/20 alle ore 06:25:25