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Titolo:
LOSS OF HIPPOCAMPAL CA1 NEURONS AND LEARNING IMPAIRMENT IN SUBICULAR LESIONED RATS
Autore:
GOVINDAIAH; RAO BSS; RAJU TR; METI BL;
Indirizzi:
NATL INST MENTAL HLTH & NEUROSCI,DEPT NEUROPHYSIOL,POST BAG 2900,HOSUR RD BANGALORE 560029 KARNATAKA INDIA NATL INST MENTAL HLTH & NEUROSCI,DEPT NEUROPHYSIOL BANGALORE 560029 KARNATAKA INDIA
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 745, anno: 1997,
pagine: 121 - 126
SICI:
0006-8993(1997)745:1-2<121:LOHCNA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; IBOTENATE LESIONS; ENTORHINAL CORTEX; MEMORY; PERFORMANCE; POSTSUBICULUM; COMPONENTS; TASK; CONNECTIONS; COMPLEX;
Keywords:
HIPPOCAMPUS; SUBICULUM; OPERANT LEARNING; ELECTROLYTIC LESION; IBOTENIC ACID LESION; ACQUISITION; RETENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
GOVINDAIAH et al., "LOSS OF HIPPOCAMPAL CA1 NEURONS AND LEARNING IMPAIRMENT IN SUBICULAR LESIONED RATS", Brain research, 745(1-2), 1997, pp. 121-126

Abstract

30-Day-old male Wistar rats were tested for acquisition and retentionof operant conditioned behavior after bilateral subicular lesions made either electrolytically or chemically (ibotenic acid). The acquisition of operant learning was carried out in lesioned rats by assessing the number of sessions required to learn the operant task, whereas the retention test was performed after lesions by assessing performance ona previously learnt operant task. The acquisition of pedal press operant learning was significantly delayed in both types of lesioned mts, without any impairment in the retention of the previously learned taskafter lesioning. In these animals the cell densities were quantified in cresyl violet-stained sections in different subfields of hippocampus. Following the lesion of subiculum, selective degeneration of CA1 cells without the involvement of other hippocampal subfields was observed. This might be due to the loss of target area (subiculum) through which hippocampus is connected with neocortical and subcortical structures. This, in turn, might have resulted in behavioral deficits. The data suggest that the subiculum might be involved in the acquisition of new information rather than in retention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:43:46