Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ENTEROVIRUS MYOCARDITIS AND DILATED CARDI OMYOPATHY
Autore:
KANDOLF R;
Indirizzi:
UNIV KLINIKUM TUBINGEN,INST PATHOL,ABT MOL PATHOL,LIEBERMEISTERSTR 8 D-72076 TUBINGEN GERMANY UNIV TUBINGEN,ABT MOL PATHOL TUBINGEN GERMANY
Titolo Testata:
Medizinische Klinik
fascicolo: 4, volume: 93, anno: 1998,
pagine: 215 - 222
SICI:
0723-5003(1998)93:4<215:EMADCO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
GER
Soggetto:
TRANSGENIC MICE; VIRAL MYOCARDITIS; COXSACKIEVIRUS B3; INTERFERON-ALPHA; PATHOGENESIS; RNA; CELLS; DNA; HYBRIDIZATION; AMPLIFICATION;
Keywords:
ENTEROVIRUS; COXSACKIEVIRUS; PERSISTENT INFECTION; IN SITU HYBRIDIZATION; INTERFERON; ANTIVIRAL THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
R. Kandolf, "ENTEROVIRUS MYOCARDITIS AND DILATED CARDI OMYOPATHY", Medizinische Klinik, 93(4), 1998, pp. 215-222

Abstract

In situ hybridization and PCR studies have demonstrated that enteroviruses of the human picornavividae, and in particular coxsackieviruses of group B (CVB), are detectable in endomyocardial biopsies of patients with acute and chronic myocarditis, indicating the possibility of enterovirus persistence in the human heart. As well, such infections areobserved in patients with end-stage dilated cardiomyopathy, suggesting an etiologic link between myocarditis and dilated cardiomyopathy. The molecular diagnosis of persistent heart muscle infection allows to differentiate myocarditis and dilated cardiomyopathy, sustained by virus persistence, from postviral immune-mediated cardiac disease. Apart from providing an etiologic diagnosis, there are therapeutic implications from in situ demonstration of myocardial enterovirus infection. As to whether antiviral therapy with interferon is capable of providing protection against enterovirus myocarditis must be determined by controlled prospective clinical studies. Immunosuppressive therapy of myocarditis appears to be justified only after exclusion of persistent heartmuscle infection. Experimental studies indicate that altered viral replication strategies, the incompetence of effector mediators of local immunity to eliminate persistently infected myocardial cells as well as infection of cellular constituents of the immune system itself, are major pathogenic determinants for development and maintenance of chronic myocarditis and cardiomyopathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:24:13