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Titolo:
ADVANCES IN THE MEDICAL-TREATMENT OF EPILEPSY
Autore:
BAZIL CW; PEDLEY TA;
Indirizzi:
COLUMBIA UNIV COLL PHYS & SURG,DEPT NEUROL NEW YORK NY 10032 COLUMBIA PRESBYTERIAN MED CTR,COMPREHENS EPILEPSY CTR NEW YORK NY 10032
Titolo Testata:
Annual review of medicine
, volume: 49, anno: 1998,
pagine: 135 - 162
SICI:
0066-4219(1998)49:<135:AITMOE>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
REFRACTORY PARTIAL EPILEPSY; GAMMA-AMINOBUTYRIC-ACID; NEWLY-DIAGNOSED EPILEPSY; PLACEBO-CONTROLLED TRIAL; POST-TRAUMATIC SEIZURES; PROPHYLACTICALLY ADMINISTERED PHENYTOIN; 1ST UNPROVOKED SEIZURE; SEVERE BRAIN INJURIES; MOUSE SPINAL NEURONS; DOSE-RANGING TRIAL;
Keywords:
SEIZURE; EPILEPSY; ANTICONVULSANT; TREATMENT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
165
Recensione:
Indirizzi per estratti:
Citazione:
C.W. Bazil e T.A. Pedley, "ADVANCES IN THE MEDICAL-TREATMENT OF EPILEPSY", Annual review of medicine, 49, 1998, pp. 135-162

Abstract

Treatment options for epilepsy, especially using antiepileptic drugs,have increased substantially in the past five years. Since 1993, fournovel antiepileptic drugs have been approved and marketed in the United States: felbamate, gabapentin, lamotrigine, and topiramate. Two others, tiagabine and vigabatrin, are likely to be approved in the near future. For many patients, these agents offer the realistic promise of improved seizure control, often with fewer adverse effects and less significant drug interactions compared with older agents. In addition, fosphenytoin, a water-soluble phenytoin prodrug with a number of advantages over intravenous phenytoin, has been released. There are new administration options for carbamazepine, diazepam, and valproic acid. Fordrug-resistant or -intolerant patients, there has been renewed interest in alternative therapies, especially the ketogenic diet. Taken together, these represent significant therapeutic advances that are benefiting patients with epilepsy. At the same time, improved understanding of the basic mechanisms of epileptogenesis, and of the cellular and molecular actions of available antiepileptic drugs, creates a framework for designing unique therapeutic strategies that are targeted at key sites of vulnerability involved in the development and maintenance of the epileptic state.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 03:13:27