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Titolo:
INHIBITORY EFFECT OF MAST CELL-MEDIATED IMMEDIATE-TYPE ALLERGIC REACTIONS IN RATS BY SPIRULINA
Autore:
KIM HM; LEE EH; CHO HH; MOON YH;
Indirizzi:
WONKWANG UNIV,COLL PHARM,DEPT ORIENTAL PHARM CHONJU 570749 SOUTH KOREA WONKWANG UNIV,SCH MED,DEPT CLIN PATHOL IKSAN 570749 CHONBUK SOUTH KOREA
Titolo Testata:
Biochemical pharmacology
fascicolo: 7, volume: 55, anno: 1998,
pagine: 1071 - 1076
SICI:
0006-2952(1998)55:7<1071:IEOMCI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTAMINE-RELEASE; SUBSTANCE-P; HUMAN-SKIN; ACTIVATION; RECEPTOR; IGE; DEGRANULATION; PROTEINS; SUBUNIT;
Keywords:
SPIRULINA; ALLERGIC REACTIONS; CAMP; TUMOR NECROSIS FACTOR-ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
H.M. Kim et al., "INHIBITORY EFFECT OF MAST CELL-MEDIATED IMMEDIATE-TYPE ALLERGIC REACTIONS IN RATS BY SPIRULINA", Biochemical pharmacology, 55(7), 1998, pp. 1071-1076

Abstract

We investigated the effect of spirulina on mast cell-mediated immediate-type allergic reactions. Spirulina dose-dependently inhibited the systemic allergic reaction induced by compound 48/80 in rats. Spirulinainhibited compound 48/80-induced allergic reaction 100% with doses of100-1000 mu g/g body weight, i.p. Spirulina (10-1000 mu g/g body weight,i.p.) also significantly inhibited local allergic reaction activated by anti-dinitrophenyl (DNP) IgE. When rats were pretreated with spirulina at a concentration ranging from 0.01 to 1000 mu g/g body weight,i.p., the serum histamine levels were reduced in a dose-dependent manner. Spirulina (0.001 to 10 mu g/mL) dose dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The level of cyclic AMP in RPMC, when spirulina (10 mu g/mL) was added, transiently and significantly increased about 70-fold at 10 sec compared with that of control cells. Moreover, spirulina (10 mu g/mL) had a significant inhibitory effect on anti-DNP IgE induced tumor necrosis factor-alpha production. These results indicate that spirulina inhibits mast cell-mediated immediate-type allergicreactions in vivo and in vitro. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:14:29