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Titolo:
COPPER-METABOLISM IN THE KIDNEY OF RATS ADMINISTERED COPPER AND COPPER-METALLOTHIONEIN
Autore:
KURASAKI M; OKABE M; SAITO S; SUZUKIKURASAKI M;
Indirizzi:
HOKKAIDO UNIV,GRAD SCH ENVIRONM EARTH SCI,DEPT ENVIRONM MED & INFORMAT,KITA KU,KITA 10,NISHI 5 SAPPORO HOKKAIDO 060 JAPAN HOKKAIDO UNIV,GRAD SCH ENVIRONM EARTH SCI,DEPT ENVIRONM MED & INFORMAT SAPPORO HOKKAIDO 060081 JAPAN
Titolo Testata:
American journal of physiology. Renal, fluid and electrolyte physiology
fascicolo: 4, volume: 43, anno: 1998,
pagine: 783 - 790
SICI:
0363-6127(1998)43:4<783:CITKOR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CADMIUM-METALLOTHIONEIN; MENKES DISEASE; CANDIDATE GENE; TIME COURSE; ATPASE; LIVER; VISUALIZATION; ACCUMULATION; DEGRADATION; THIONEIN;
Keywords:
AUTOFLUORESCENCE; IN SITU BLOTTING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M. Kurasaki et al., "COPPER-METABOLISM IN THE KIDNEY OF RATS ADMINISTERED COPPER AND COPPER-METALLOTHIONEIN", American journal of physiology. Renal, fluid and electrolyte physiology, 43(4), 1998, pp. 783-790

Abstract

To gain a greater understanding of the mechanism of Cu metabolism in kidneys of rats, using autofluorescence of Cu-metallothioneins (Cu-MTs) we revealed the behavior of Cu-MT in the kidneys of rats administered Cu-MT. Yellow and orange fluorescent signals of Cu-MT were observed in the cortex. By microscopic studies, Cu-MT was dominant in the proximal convolute tubular cells of the cortex. A high concentration of Cu-MT presented in the lysosome-like organelles of the proximal convolutetubular adjacent to the glomeruli. During the time course after the injection, the orange signal in lysosome-like organelles gradually converted to a yellow signal, indicating that the Cu-MT was involved in a degradation process in lysosomes by oxidation, and the MT mRNA increased in the cortex, although the immunoreactivity of MT was almost constant in the same region. These results suggested that Cu bound to the injected MT was released in lysosomes and became a new inducer of MT biosynthesis in the cortex. In conclusion, the biosynthesis and degradation of Cu-MT occur repeatedly in the proximal convolute tubular cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:08:54