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Titolo:
SYNTHESIS OF A RADIOTRACER FOR STUDYING NICOTINIC ACETYLCHOLINE-RECEPTORS - 2-[F-18]FLUORO-3-(2(S)-AZETIDINYLMETHOXY)PYRIDINE (2-[F-18]A-85380)
Autore:
HORTI AG; KOREN AO; RAVERT HT; MUSACHIO JL; MATHEWS WB; LONDON ED; DANNALS RF;
Indirizzi:
JOHNS HOPKINS MED INST,DIV NUCL MED,600 N WOLFE ST,NELSON B1-167 BALTIMORE MD 21287 JOHNS HOPKINS MED INST,DIV RADIAT HLTH SCI BALTIMORE MD 21287 NIDA,BRAIN IMAGING CTR,INTRAMURAL RES PROGRAM BALTIMORE MD 21224
Titolo Testata:
Journal of labelled compounds & radiopharmaceuticals
fascicolo: 4, volume: 41, anno: 1998,
pagine: 309 - 318
SICI:
0362-4803(1998)41:4<309:SOARFS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL-CORTEX; BINDING-SITES;
Keywords:
RADIOTRACER; A-85380; F-18; FLUORINATION; HALOGEN-EXCHANGE; NICOTINIC RECEPTORS; ACETYLCHOLINE; POSITRON EMISSION TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
A.G. Horti et al., "SYNTHESIS OF A RADIOTRACER FOR STUDYING NICOTINIC ACETYLCHOLINE-RECEPTORS - 2-[F-18]FLUORO-3-(2(S)-AZETIDINYLMETHOXY)PYRIDINE (2-[F-18]A-85380)", Journal of labelled compounds & radiopharmaceuticals, 41(4), 1998, pp. 309-318

Abstract

The radiochemical synthesis of 2-[F-18]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[F-18]A-85380, [F-18](1) under bar 1) was accomplished by Kryptofix(R) 222 assisted nucleophilic no-carrier-added [F-18]fluorination of 2-iodo-3-((1-tert-butoxycarbonyl-2 -(S)-azetidinyl)methoxy)pyridine, (2) under bar followed by acidic deprotection. The average radiochemical yield was 10% and the average specific radioactivity was 1050 mCi/mu mol, calculated at end-of-synthesis (EOS).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 13:03:39