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Titolo:
APOPTOSIS OF GUINEA-PIG COCHLEAR HAIR-CELLS FOLLOWING CHRONIC AMINOGLYCOSIDE TREATMENT
Autore:
NAKAGAWA T; YAMANE H; TAKAYAMA M; SUNAMI K; NAKAI Y;
Indirizzi:
YODOGAWA CHRISTIANS HOSP,DEPT OTORHINOLARYNGOL,2-9-26 AWAJI HIGASHIYODOGAWA KU OSAKA 533 JAPAN OSAKA CITY UNIV,SCH MED,DEPT OTORHINOLARYNGOL OSAKA 545 JAPAN
Titolo Testata:
European archives of oto-rhino-laryngology
fascicolo: 3, volume: 255, anno: 1998,
pagine: 127 - 131
SICI:
0937-4477(1998)255:3<127:AOGCHF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INNER-EAR; SENSORY EPITHELIA; ACOUSTIC TRAUMA; REGENERATION; DEATH;
Keywords:
COCHLEA; AMINOGLYCOSIDE TOXICITY; HAIR CELL APOPTOSIS; NICK-END LABELING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
T. Nakagawa et al., "APOPTOSIS OF GUINEA-PIG COCHLEAR HAIR-CELLS FOLLOWING CHRONIC AMINOGLYCOSIDE TREATMENT", European archives of oto-rhino-laryngology, 255(3), 1998, pp. 127-131

Abstract

Although aminoglycosides have been investigated for their cochleotoxicity, it has still not been determined whether apoptosis or necrosis results in cochlear hair cell death following aminoglycoside treatment. To study possible mechanisms of cell death, we used in situ DNA break-labeling to examine guinea pig cochleae affected by kanamycin ototoxicity. Chronic kanamycin treatment induced DNA fragmentation that was detectable in both outer and inner hair cells, suggesting the occurrence of apoptosis. These findings suggest that apoptosis achieves deletion of affected hair cells without disrupting tissue architecture in theorgan of Corti.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 07:51:52