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Titolo:
SYNTHESIS, SAR AND PHARMACOLOGY OF CP-293,019 - A POTENT, SELECTIVE DOPAMINE D-4 RECEPTOR ANTAGONIST
Autore:
SANNER MA; CHAPPIE TA; DUNAISKIS AR; FLIRI AF; DESAI KA; ZORN SH; JACKSON ER; JOHNSON CG; MORRONE JM; SEYMOUR PA; MAJCHRZAK MJ; FARACI WS; COLLINS JL; DUIGNAN DB; DIPRETE CC; LEE JS; TROZZI A;
Indirizzi:
PFIZER INC,PFIZER CENT RES,EASTERN POINT RD GROTON CT 06340
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 7, volume: 8, anno: 1998,
pagine: 725 - 730
SICI:
0960-894X(1998)8:7<725:SSAPOC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-AFFINITY; AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Sanner et al., "SYNTHESIS, SAR AND PHARMACOLOGY OF CP-293,019 - A POTENT, SELECTIVE DOPAMINE D-4 RECEPTOR ANTAGONIST", Bioorganic & medicinal chemistry letters, 8(7), 1998, pp. 725-730

Abstract

A series of novel, potent and selective pyrido[1,2-a]pyrazine dopamine D-4 receptor antagonists are reported including CP-293,019 (D-4 K-i = 3.4 nM, D-2 K-i > 3,310 nM), which also inhibits apomorphine-inducedhyperlocomotion in rats after oral dosing. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 15:59:30