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Titolo:
GATA FACTOR-DEPENDENT REGULATION OF CARDIAC M2 MUSCARINIC ACETYLCHOLINE GENE-TRANSCRIPTION
Autore:
ROSOFF ML; NATHANSON NM;
Indirizzi:
UNIV WASHINGTON,DEPT PHARMACOL,BOX 357750 SEATTLE WA 98195 UNIV WASHINGTON,DEPT PHARMACOL SEATTLE WA 98195
Titolo Testata:
The Journal of biological chemistry
fascicolo: 15, volume: 273, anno: 1998,
pagine: 9124 - 9129
SICI:
0021-9258(1998)273:15<9124:GFROCM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMBRYONIC-DEVELOPMENT; DEVELOPING HEART; PROMOTER REGION; RECEPTOR GENE; EXPRESSION; CELLS; FAMILY; GATA-4/5/6;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Rosoff e N.M. Nathanson, "GATA FACTOR-DEPENDENT REGULATION OF CARDIAC M2 MUSCARINIC ACETYLCHOLINE GENE-TRANSCRIPTION", The Journal of biological chemistry, 273(15), 1998, pp. 9124-9129

Abstract

The m2 subtype is the predominant muscarinic acetylcholine receptor subtype expressed in heart and regulates the rate and force of cardiac contraction. We have previously reported the isolation of the promoterregion for the chick m2 receptor gene and defined a region of the chick m2 promoter sufficient for high level expression in cardiac primarycultures. In this manuscript we demonstrate transactivation of cm2 promoter by the GATA family of transcription factors. In addition, we define the GATA-responsive element in the chick m2 promoter and demonstrate that this element is required for expression in cardiac primary cultures. Finally, we demonstrate specific binding of both a chick heartnuclear protein and of cloned chick GATA-4, -5, and -6 to the GATA-responsive element.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 06:40:14