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Titolo:
THE EFFECTS OF CONVULSANT AND ANTICONVULSANT TREATMENTS ON THE BEHAVIORAL-EFFECTS OF ULTRASOUND PRESENTATION IN LISTER HOODED RATS
Autore:
COMMISSARIS RL; BECKETT SRG; MARSDEN CA;
Indirizzi:
WAYNE STATE UNIV,COLL PHARM & ALLIED HLTH PROFESS,DEPT PHARMACEUT SCIDETROIT MI 48202 UNIV NOTTINGHAM,DEPT PHYSIOL & PHARMACOL NOTTINGHAM NG7 2RD ENGLAND
Titolo Testata:
Behavioural pharmacology
fascicolo: 2, volume: 9, anno: 1998,
pagine: 113 - 126
SICI:
0955-8810(1998)9:2<113:TEOCAA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED DEFENSE BEHAVIOR; EPILEPSY-PRONE RAT; AUDIOGENIC-SEIZURES; ANIMAL-MODELS; WITHDRAWAL; ETHANOL; PENTYLENETETRAZOL; TOLERANCE; STIMULUS; NEURONS;
Keywords:
ANTICONVULSANTS; ANXIETY; ANXIOLYTICS; AUDIOGENIC SEIZURES; CONVULSANTS; DEFENSE RESPONSE; FEAR; PANIC ATTACKS; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Commissaris et al., "THE EFFECTS OF CONVULSANT AND ANTICONVULSANT TREATMENTS ON THE BEHAVIORAL-EFFECTS OF ULTRASOUND PRESENTATION IN LISTER HOODED RATS", Behavioural pharmacology, 9(2), 1998, pp. 113-126

Abstract

Lister hooded rats exhibit bursts of locomotion when exposed to a 20 kHz acoustic stimulus; this ultrasound-induced locomotion has been suggested as a potential model for panic attacks. The present studies determined the effects of treatment with the convulsant agents strychnineand pentylenetetrazole and the anticonvulsant agents pentobarbital and ethosuximide on locomotor behaviour elicited by experimenter-presented ultrasounds in Lister hooded rats. Behaviour in a circular arena was viewed live and tracked electronically. In Experiment 1, brief exposure to an ultrasound stimulus typically resulted in short intensity-related bursts of locomotion in control rats. Pentobarbital or ethosuximide treatment reduced this short-term ultrasound-induced locomotion ina dose-related manner, whereas pentylenetetrazole or strychnine treatment increased these locomotor bursts. In Experiment 2, exposure to the ultrasound stimulus for a longer period resulted in irregular cyclesof bursts of locomotion followed by periods of relative inactivity incontrol rats. In addition, approximately 10% of control rats exhibited convulsions associated with this long-duration ultrasound exposure at 98 dB sound pressure level. Sub-convulsant doses of the convulsant treatments increased the frequency of occurrence of convulsions associated with the ultrasound stimulus; pentobarbital or ethosuximide pretreatment significantly reduced this effect. The present findings suggestthat a relationship exists between ultrasound-induced locomotor bursts and convulsant activity. (C) 1998 Rapid Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:25:23