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Titolo:
DOSE-RELATED ETHANOL-LIKE EFFECTS OF THE NMDA ANTAGONIST, KETAMINE, IN RECENTLY DETOXIFIED ALCOHOLICS
Autore:
KRYSTAL JH; PETRAKIS IL; WEBB E; COONEY NL; KARPER LP; NAMANWORTH S; STETSON P; TREVISAN LA; CHARNEY DS;
Indirizzi:
YALE UNIV,DEPT PSYCHIAT,SCHIZOPHRENIA BIOL RES CTR,SCH MED,950 CAMPBELL AVE,VAMC 116A W HAVEN CT 06516 YALE UNIV,ALCOHOL RES CTR W HAVEN CT 00000 UNIV MICHIGAN,SCH MED,DEPT PHARMACOL,UPJOHN RES INST ANN ARBOR MI 48109
Titolo Testata:
Archives of general psychiatry
fascicolo: 4, volume: 55, anno: 1998,
pagine: 354 - 360
SICI:
0003-990X(1998)55:4<354:DEEOTN>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISCRIMINATIVE STIMULUS PROPERTIES; D-ASPARTATE RECEPTOR; EFFECTS SCALE; MK-801; RAT; DEPENDENCE; SCHIZOPHRENIA; ACAMPROSATE; INHIBITION; VALIDATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Krystal et al., "DOSE-RELATED ETHANOL-LIKE EFFECTS OF THE NMDA ANTAGONIST, KETAMINE, IN RECENTLY DETOXIFIED ALCOHOLICS", Archives of general psychiatry, 55(4), 1998, pp. 354-360

Abstract

Background: This study evaluated the dose-related ethanol-like subjective effects of the N-methyl-D-aspartate (NMDA) glutamate receptor antagonist ketamine hydrochloride in recently detoxified alcoholics. Methods: Twenty male inpatients meeting DSM-III-R criteria for alcohol dependence and who had not consumed alcohol for 10 to 27 days prior to the study completed 3 test days that involved the intravenous infusion of ketamine hydrochloride (0.1 mg/kg or 0.5 mg/kg) or saline solution under randomized double-blind conditions. Ethanol-like subjective effects were assessed using the Sensation Scale; the Biphasic Alcohol Effects Scale; visual analog scales to measure ''high'' and degree of similarity to ethanol, cocaine, and marijuana; a scale assessing the numberof standard alcohol drinks producing similar subjective effects; and visual analog scales measuring ethanol craving. Results: Ketamine produced dose-related ethanol-like effects on each scale measuring its similarity to ethanol. Its effects were more similar to the sedative or descending limb effects of ethanol than to the stimulant or ascending limb effects. Ketamine effects also were more like ethanol than marijuana or cocaine. Ethanol-like effects were more prominent at the higher ketamine dose, a dose rated as similar to greater levels of ethanol intoxication However, ketamine did not increase craving for ethanol. Conclusion: The production of ethanol-like subjective effects by ketaminesupports the potential clinical importance of NMDA receptor antagonism among the mechanisms underlying the subjective effects of ethanol inhumans.

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Documento generato il 22/01/20 alle ore 06:58:21