Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
USE OF PATTERN-ANALYSIS TO PREDICT DIFFERENTIAL RELAPSE OF REMITTED PATIENTS WITH MAJOR DEPRESSION DURING 1 YEAR OF TREATMENT WITH FLUOXETINE OR PLACEBO
Autore:
STEWART JW; QUITKIN FM; MCGRATH PJ; AMSTERDAM J; FAVA M; FAWCETT J; REIMHERR F; ROSENBAUM J; BEASLEY C; ROBACK P;
Indirizzi:
UNIT 35,1051 RIVERSIDE DR NEW YORK NY 10032 NEW YORK STATE PSYCHIAT INST & HOSP,DEPT PSYCHIAT NEW YORK NY 10032 MASSACHUSETTS GEN HOSP,DEPT PSYCHIAT BOSTON MA 02114 RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT PSYCHIAT CHICAGO IL 60612 UNIV UTAH,DEPT PSYCHIAT SALT LAKE CITY UT 00000 ELI LILLY CORP INDIANAPOLIS IN 00000 COLORADO STATE UNIV,DEPT STAT FT COLLINS CO 80523 UNIV PENN,DEPT PSYCHIAT PHILADELPHIA PA 19104
Titolo Testata:
Archives of general psychiatry
fascicolo: 4, volume: 55, anno: 1998,
pagine: 334 - 343
SICI:
0003-990X(1998)55:4<334:UOPTPD>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRUE DRUG RESPONSE; ANTIDEPRESSANT DRUGS; DOWN-REGULATION; RECEPTOR; RATS; PHARMACOLOGY; DESIPRAMINE; IMIPRAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Stewart et al., "USE OF PATTERN-ANALYSIS TO PREDICT DIFFERENTIAL RELAPSE OF REMITTED PATIENTS WITH MAJOR DEPRESSION DURING 1 YEAR OF TREATMENT WITH FLUOXETINE OR PLACEBO", Archives of general psychiatry, 55(4), 1998, pp. 334-343

Abstract

Background: Delayed and persistent (''true drug'') improvement characterizes the response to antidepressant medication. Early or nonpersistent (''placebo'') benefit is typical of a placebo response. The prediction was that patients with a true drug response would sustain their benefit best if they continued to receive the drug and that patients with a placebo response would have an equivalent prognosis whether they continued to receive the drug or were switched to placebo. Methods: Patients with major depression who met the study's response criteria (a modified Hamilton Depression Rating Scale score less than or equal to 7 and failure to meet major depression criteria after each of the last3 weeks following 12 to 14 weeks of treatment with fluoxetine hydrochloride, 20 mg/d) were enrolled in a 50-week randomized placebo substitution trial during which the return of depressive symptoms defined relapse. The timing and persistency of response during initial treatment defined true drug or placebo response patterns. Results: Patients witha true drug response pattern relapsed significantly more frequently if they were switched to placebo than if they continued to receive fluoxetine (P<.001 for weeks 12-26, P<.005 for weeks 26-50, and P<.41 for weeks 50-62). Patients with a placebo response pattern had an equivalent outcome whether maintained on fluoxetine therapy or placebo (P<.20 for weeks 12-26, test invalid for weeks 26-50, and P<.67 for weeks 50-62). Patients with a placebo response pattern relapsed more often whenthey continued to receive fluoxetine than patients with a true drug response pattern (P<.01 for weeks 12-26, P<.10 for weeks 26-50, and P<.36 for weeks 50-62). Conclusions: These findings confirm that pattern analysis validly differentiates true drug from nonspecific initial responses and extend its use to the continuation and maintenance phases of treatment for depression. Investigations into the mechanisms of antidepressant activity might best be limited to those that can account for delayed efficacy. Fluoxetine's efficacy during the continuation and maintenance phases of treatment may be limited to patients with a truedrug pattern of initial response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:38:28