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Titolo:
THE REPLICATION MECHANISM OF KINETOPLAST DNA NETWORKS IN SEVERAL TRYPANOSOMATID SPECIES
Autore:
GUILBRIDE DL; ENGLUND PT;
Indirizzi:
JOHNS HOPKINS MED SCH,DEPT BIOL CHEM BALTIMORE MD 21205
Titolo Testata:
Journal of Cell Science
, volume: 111, anno: 1998,
parte:, 6
pagine: 675 - 679
SICI:
0021-9533(1998)111:<675:TRMOKD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRITHIDIA-FASCICULATA; RIBOSOMAL-RNAS; 2 SITES; MINICIRCLES; EVOLUTION; PROTOZOA; BRUCEI; TOPOISOMERASE; LOCALIZATION; PARASITISM;
Keywords:
KINETOPLAST DNA; TRYPANOSOMATID; REPLICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Guilbride e P.T. Englund, "THE REPLICATION MECHANISM OF KINETOPLAST DNA NETWORKS IN SEVERAL TRYPANOSOMATID SPECIES", Journal of Cell Science, 111, 1998, pp. 675-679

Abstract

Kinetoplast DNA, a giant network of interlocked DNA circles, replicates by an unusual mechanism. Minicircles are released individually fromthe network by a topoisomerase II, and then, after replication, theirprogeny are reattached at antipodal positions on the network periphery. Studies to date have revealed two distinct variations on this model. In Crithidia fasciculata the newly replicated minicircles quickly become uniformly distributed around the network periphery, whereas in Trypanosoma brucei the minicircles accumulate near their two points of attachment. The kinetoplast DNA replication mechanism used by other related trypanosomatid species was until now unknown. Here we used a novel method, involving fluorescence microscopy of isolated networks, to investigate kinetoplast DNA replication in Leishmania tarentolae, Leishmania donovani, Trypanosoma cruzi and Phytomonas serpens. We found that all of these species have a replication mechanism resembling that ofC. fasciculata and that the polar replication mechanism observed in T. brucei is so far unique to this species.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:54:47