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Titolo:
SITE OF OPIOID ACTION IN THE HUMAN BRAIN - MU-AGONIST AND KAPPA-AGONIST SUBJECTIVE AND CEREBRAL BLOOD-FLOW EFFECTS
Autore:
SCHLAEPFER TE; STRAIN EC; GREENBERG BD; PRESTON KL; LANCASTER E; BIGELOW GE; BARTA PE; PEARLSON GD;
Indirizzi:
UNIV HOSP BERN,DEPT PSYCHIAT,PSYCHIAT NEUROIMAGING GRP,MURTENSTR 21 CH-3010 BERN SWITZERLAND JOHNS HOPKINS MED INST,DEPT PSYCHIAT,DIV PSYCHIAT NEUROIMAGING BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DEPT PSYCHIAT,BEHAV PHARMACOL RES UNIT BALTIMORE MD 21205 NIMH,CLIN SCI LAB BETHESDA MD 20892 NIDA,ADDICT RES CTR BALTIMORE MD 21224
Titolo Testata:
The American journal of psychiatry
fascicolo: 4, volume: 155, anno: 1998,
pagine: 470 - 473
SICI:
0002-953X(1998)155:4<470:SOOAIT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRECIPITATED WITHDRAWAL; DRUG DISCRIMINATION; ANTAGONIST OPIOIDS; OPIATE RECEPTOR; HYDROMORPHONE; MORPHINE; COCAINE; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
T.E. Schlaepfer et al., "SITE OF OPIOID ACTION IN THE HUMAN BRAIN - MU-AGONIST AND KAPPA-AGONIST SUBJECTIVE AND CEREBRAL BLOOD-FLOW EFFECTS", The American journal of psychiatry, 155(4), 1998, pp. 470-473

Abstract

Objective: Humans experience the subjective effects of mu and kappa opioid agonists differently: mu agonists produce mainly euphoria, whilekappa agonists are more likely to produce dysphoria. This study tested the hypothesis that these subjective effects would be associated with anatomically distinct changes in regional cerebral blood flow (CBF) relative to baseline as assessed with single photon emission computed tomography (SPECT). Method: Nine nondependent opioid abusers participated in the study. In the first phase of the study, the participants were acclimated to effects of the study drugs. In the second phase they underwent repeat challenges with the study drugs followed by an assessment of CBF with use of the SPECT tracer [99mTc]HMPAO. Medications tested were the prototypic mu agonist hydromorphone, the mixed agonist/antagonist butorphanol (which has a kappa agonist component of activity), and saline placebo. Results: Subjective effects of the drugs were distinctly different. Hydromorphone produced increased ratings of ''goodeffects,'' while butorphanol led to more ''bad effects. '' Hydromorphone significantly increased regional CBF in the anterior cingulate cortex, both amygdalae, and the thalamus-all structures belonging to the limbic system. Butorphanol caused a less distinct picture of regional CBF increases, mainly in the area of both temporal lobes. Conclusions: This study demonstrates that opioids with different subjective effectsalso produce statistically significant patterns of change in regionalCBF from baseline, and the regions of statistical significance appearin different brain regions. In addition, these results demonstrate the applicability of SPECT functional neuroimaging in the study of medications with potential abuse liability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:19:12