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Titolo:
EXPRESSION OF CELL CYCLE-RELATED GENES DURING NEURONAL APOPTOSIS - ISTHERE A DISTINCT PATTERN
Autore:
SHIRVAN A; ZIV I; ZILKHAFALB R; MACHLYN T; BARZILAI A; MELAMED E;
Indirizzi:
RABIN MED CTR,FELSENSTEIN MED RES CTR,BEILINSON CAMPUS IL-49100 PETAHTIQWA ISRAEL RABIN MED CTR,DEPT NEUROL IL-49100 PETAH TIQWA ISRAEL TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT NEUROBIOCHEM IL-69978 TEL AVIV ISRAEL
Titolo Testata:
Neurochemical research
fascicolo: 5, volume: 23, anno: 1998,
pagine: 767 - 777
SICI:
0364-3190(1998)23:5<767:EOCCGD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC NEURONS; PARKINSONS-DISEASE; PC12 CELLS; DEATH; INDUCTION; KINASE; DIFFERENTIATION; PROTEIN; P53; D1;
Keywords:
POSTMITOTIC NEURONS; OXIDATIVE-STRESS; CELL-CYCLE; APOPTOSIS; CYCLIN B; CDK5;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
A. Shirvan et al., "EXPRESSION OF CELL CYCLE-RELATED GENES DURING NEURONAL APOPTOSIS - ISTHERE A DISTINCT PATTERN", Neurochemical research, 23(5), 1998, pp. 767-777

Abstract

An emerging hypothesis considers the process of neuronal apoptosis asa consequence of unscheduled and unsynchronized induction of cell cycle mediators, Induction of several cell cycle genes precedes neuronal apoptosis and may be involved in determination of cell fate. We have now characterized changes in expression of cell cycle genes during apoptosis induced by oxidative stress in chick post-mitotic sympathetic neurons. Induction of cyclin B occurred prior to the commitment of neurons to both dopamine-and peroxide-triggered apoptosis. Both the neuronal death and the rise in cyclin B were inhibited by antioxidant treatment, suggesting a functional role for cyclin B induction during neuronal apoptosis, Induction of the cyclin dependent kinase CDK5 protein coincided with the time point when neurons were irreversibly committed todie. Expression of other cell cycle mediators such as cyclin D1 and the cyclin dependent kinases CDC2 and CDK2 was undetected and not induced by exposure to oxidative stress. Comparative analysis of the profile of cell cycle mediators induced during neuronal apoptosis of different neuronal cell populations revealed no distinct pattern of events. There are no cell cycle stage-specific mediators that are ultimately stimulated during neuronal apoptosis, suggesting that multiple pathways of re-activating the dormant cell-cycle, converge to determine entry into apoptosis. Nevertheless, the existence of some cell cycle mediators, that were not reported so far to be induced in post mitotic neuronsduring oxidative stress, substantiate them as part of the strong differentiating forces.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:45:33