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Titolo:
EFFECT OF THEANINE, R-GLUTAMYLETHYLAMIDE, ON BRAIN MONOAMINES AND STRIATAL DOPAMINE RELEASE IN CONSCIOUS RATS
Autore:
YOKOGOSHI H; KOBAYASHI M; MOCHIZUKI M; TERASHIMA T;
Indirizzi:
UNIV SHIZUOKA,SCH FOOD & NUTR SCI,LAB NUTR BIOCHEM,52-1 YADA SHIZUOKA422 JAPAN
Titolo Testata:
Neurochemical research
fascicolo: 5, volume: 23, anno: 1998,
pagine: 667 - 673
SICI:
0364-3190(1998)23:5<667:EOTROB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; BLOOD-PRESSURE; PHYSIOLOGICAL DEPENDENCE; AMINO-ACIDS; PROTEIN; TRANSPORT; BARRIER; 5-HYDROXYINDOLES; CATECHOLAMINES; METHIONINE;
Keywords:
THEANINE; SEROTONIN; DOPAMINE; MICRODIALYSIS; GLUTAMATE RECEPTOR; NMDA RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
H. Yokogoshi et al., "EFFECT OF THEANINE, R-GLUTAMYLETHYLAMIDE, ON BRAIN MONOAMINES AND STRIATAL DOPAMINE RELEASE IN CONSCIOUS RATS", Neurochemical research, 23(5), 1998, pp. 667-673

Abstract

Theanine, r-glutamylethylamide, is one of the major components of amino acids in Japanese green tea. Effect of theanine on brain amino acids and monoamines, and the striatal release of dopamine (DA) was investigated. Determination of amino acids in the brain after the intragastric administration of theanine showed that theanine was incorporated into brain through blood-brain barrier via leucine-preferring transport system. The concentrations of norepinephrine, 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindole acetic acid (5HIAA) in the brain regions were unaffected by the theanine administration except in striatum. Theanine administration caused significant increases in serotonin and/or DA concentrations in the brain, especially in striatum, hypothalamus and hippocampus. Direct administration of theanine into brain striatum by microinjection caused a significant increase of DA release ina dose-dependent manner. Microdialysis of brain with calcium-free Ringer buffer attenuated the theanine-induced DA release. Pretreatment with the Ringer buffer containing an antagonist of non-NMDA (N-methyl-D-aspartate) glutamate receptor, MK-801, for 1 hr did not change the significant increase of DA release induced by theanine. However, in the case of pretreatment with AP-5, (+/-)-2-amino-5-phosphonopentanoic acid; antagonist of NMDA glutamate receptor, the theanine-induced DA release from striatum was significantly inhibited. These results suggest that theanine might affect the metabolism and/or the release of some neurotransmitters in the brain, such as DA.

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Documento generato il 01/12/20 alle ore 10:54:33