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Titolo:
DISPARATE ROLES FOR TNF-ALPHA AND FAS LIGAND IN CONCANAVALIN A-INDUCED HEPATITIS
Autore:
KSONTINI R; COLAGIOVANNI DB; JOSEPHS MD; EDWARDS CK; TANNAHILL CL; SOLORZANO CC; NORMAN J; DENHAM W; CLARESALZLER M; MACKAY SLD; MOLDAWER LL;
Indirizzi:
UNIV FLORIDA,COLL MED,DEPT SURG,JHMHSC,BOX 100286 GAINESVILLE FL 32610 UNIV FLORIDA,COLL MED,DEPT SURG,JHMHSC GAINESVILLE FL 32610 AMGEN INC BOULDER CO 80301 UNIV S FLORIDA,DEPT SURG TAMPA FL 33612
Titolo Testata:
The Journal of immunology
fascicolo: 8, volume: 160, anno: 1998,
pagine: 4082 - 4089
SICI:
0022-1767(1998)160:8<4082:DRFTAF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; ICE/CED-3 PROTEASE; LIVER-INJURY; APOPTOSIS; MICE; DEATH; ACTIVATION; CD95; INVOLVEMENT; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
R. Ksontini et al., "DISPARATE ROLES FOR TNF-ALPHA AND FAS LIGAND IN CONCANAVALIN A-INDUCED HEPATITIS", The Journal of immunology, 160(8), 1998, pp. 4082-4089

Abstract

Apoptosis is a physiologic process that serves to eliminate cells during development or in response to immunologic regulation In acute inflammation, however. apoptosis triggered by the overproduction of ''death factors'' such as TNF-alpha or Fas ligand (FasL) may contribute to tissue injury, Both TNF-alpha and Fast are presumed to convey an apoptotic signal by activating a cascade of cysteine-aspartate proteases, which includes IL-1 beta-converting enzyme or caspase-1, In the present study, we evaluated the contribution of TNF-alpha and FasL, as well asthe role of caspase-1, in Con A-induced hepatitis, me report here that TNF-alpha and FasL. mRNA and protein levels are both increased in the livers of Con A-challenged mice, Using a novel inhibitor of TNF-alpha, we can confirm that Con A-induced hepatitis is primarily TNF-alpha dependent, Blockade of Fast with a soluble Fas immunoadhesin does not prevent liver injury in animals treated with Con A alone, However, administration of a matrix metalloproteinase inhibitor exacerbates liver injury, in part through a FasL-dependent process, since pretreatment with the soluble Fas immunoadhesin reduces liver injury in this model, In addition, mice lacking functional caspase-1 are resistant to Con A-induced hepatitis, even after pretreatment with a matrix metalloproteinase inhibitor, We conclude that TNF-alpha plays a predominant role inCon A-induced liver injury, although concomitant activation of Fast can also lend to apoptotic injury, Furthermore, Con A-induced hepatitisis caspase-1 dependent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:16:52