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Titolo:
IMAGING OF CEREBRAL BLOOD-FLOW WITH TECHNETIUM-99M-HMPAO AND TECHNETIUM-99M-ECD - A COMPARISON
Autore:
ASENBAUM S; BRUCKE T; PIRKER W; PIETRZYK U; PODREKA I;
Indirizzi:
UNIV VIENNA,DEPT NEUROL,WAHRINGER GURTER 18-20 A-1090 VIENNA AUSTRIA UNIV VIENNA,DEPT NUCL MED A-1090 VIENNA AUSTRIA KA RUDOLFSSTIFTUNG,DEPT NEUROL VIENNA AUSTRIA MAX PLANCK INST NEUROL RES COLOGNE GERMANY
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 4, volume: 39, anno: 1998,
pagine: 613 - 618
SICI:
0161-5505(1998)39:4<613:IOCBWT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ETHYL CYSTEINATE DIMER; NONHUMAN-PRIMATES; SPECT IMAGES; TC-99M HMPAO; PERFUSION; BRAIN; RETENTION; ECD; PET; L,L-ECD;
Keywords:
CEREBRAL BLOOD FLOW; TECHNETIUM-99M-ECD; TECHNETIUM-99M-HMPAO; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
S. Asenbaum et al., "IMAGING OF CEREBRAL BLOOD-FLOW WITH TECHNETIUM-99M-HMPAO AND TECHNETIUM-99M-ECD - A COMPARISON", The Journal of nuclear medicine, 39(4), 1998, pp. 613-618

Abstract

Because Tc-99m-HMPAO and Tc-99m-ECD are both used for SPECT imaging of cerebral blood flow, the question arises whether there are any differences in their respective regional cerebral distribution, For that purpose, visual and semiquantitative comparisons between Tc-99m-HMPAO and Tc-99m-ECD studies were performed. Methods: Seventeen patients (4 women; 13 men; age 45-89 yr; mean age 71 yr) with various neurological diseases, except acute/subacute stroke, were investigated twice with (TC)-T-99m-HMPAO and Tc-99M-ECD using a triple-headed rotating SPECT camera. After image reorientation, the two studies were evaluated visually. Seventy regions of interest (ROls) were drawn manually and the sameset of ROls was applied in both studies. Regional indices (RI) normalized to individual brain values were calculated and first compared between two random patient groups. Second, for all patients, RI for 70 and later for 27 regions (gained after summing values of corresponding regions in different brain slices) were compared by using a paired Student's t-test applying Bonferroni's correction. Results: Visual evaluation demonstrated relatively high Tc-99m-ECD uptake in occipital and comparatively low uptake in mediotemporal regions. Calculation of RI revealed significantly higher values in the right cerebellum, brainstem, mediotemporal regions, right basal ganglia and the thalamus in the Tc-99m-HMPAO SPECT Studies and higher values in the occipital, supratemporal/inferior parietal and parietal cortex in the Tc-99m-ECD SPECT studies, respectively. Conclusion: Significant differences in regional tracer distribution between (TC)-T-99m-HMPAO and Tc-99m-ECD could be detected, probably caused by different tracer kinetics, The results indicate that direct comparisons of studies performed with (TC)-T-99m-HMPAO and Tc-99m-ECD are not possible and the use of either tracer can be favorable in different clinical questions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:36:27