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Titolo:
HYPOFRONTALITY AND NEGATIVE SYMPTOMS IN MAJOR DEPRESSIVE DISORDER
Autore:
GALYNKER II; CAI J; ONGSENG F; FINESTONE H; DUTTA E; SERSENI D;
Indirizzi:
ALBERT EINSTEIN COLL MED,BETH ISRAEL MED CTR,DEPT PSYCHIAT,6 KARPAS,1ST AVE 16TH ST NEW YORK NY 10003 ALBERT EINSTEIN COLL MED,BETH ISRAEL MED CTR,DEPT RADIOL NEW YORK NY 10003
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 4, volume: 39, anno: 1998,
pagine: 608 - 612
SICI:
0161-5505(1998)39:4<608:HANSIM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; CHRONIC-SCHIZOPHRENIA; GLUCOSE-METABOLISM; SLEEP-DEPRIVATION; PREFRONTAL CORTEX; BASAL GANGLIA; FRONTAL-LOBE; DISEASE; HYPOMETABOLISM;
Keywords:
TECHNETIUM-99M-HMPAO SPECT; REGIONAL CEREBRAL BLOOD FLOW; DEPRESSION; NEGATIVE SYMPTOMS; DORSOLATERAL PREFRONTAL CORTEX; TEMPORAL CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
I.I. Galynker et al., "HYPOFRONTALITY AND NEGATIVE SYMPTOMS IN MAJOR DEPRESSIVE DISORDER", The Journal of nuclear medicine, 39(4), 1998, pp. 608-612

Abstract

The purpose of the current study was to compare regional cerebral blood flow (rCBF) in patients with major depressive disorder (MDD) to that of healthy subjects and to examine the relationship between rCBF, depressive symptoms (DS) and negative symptoms (NS) in these patients. Methods: Eleven psychiatric inpatients with diagnosed (MDD) and 15 normal control subjects were administered the scale for the assessment of negative symptoms (SANS) and the modified Hamilton rating scale for depression with items descriptive of NS excluded (HRSD-DS). Each patientunderwent a SPECT scan using Tc-99m-HMPAO at rest. Cortical and subcortical regions of interest (ROls) were symmetrically defined in each hemisphere. Cortical-to-cerebellar perfusion ratios were established quantitatively using ADAC software, Results: Subjects in the MDD group had significantly lower rCBF in the frontal cortex and cinglulate gyrus(MANOVA, p = 0.038) due to differences in dorsolateral prefrontal cortex bilaterally (right F = 7.69, p = 0.01; left F = 8.41, p = 0.01) inthe right orbitofrontal cortex (F = 6.79, p = 0.02) and in the cingulate gyrus (F = 5.34, p = 0.03). The MDD group also had lower rCBF in the posterior cortical structures (MANOVA, p = 0.072), which was due todecreased perfusion in the right parietal cortex (F = 7.54, p = 0.01), There were negative correlations between the SANS total score and rCBF in both the left dorsolateral prefrontal cortex (Pearson's correlation coefficient r =.-67, p < 0.05) and the left anterior temporal cortex (r = -0.71, p < 0.01) in MDD patients. Additionally, there were positive correlations between HRSD scores and rCBF in the left anterior temporal (r = 0.71, p < 0.01), left dorsolateral prefrontal (r = 0.70, p < 0.01), right frontal (r = 0.82, p ( 0.01) and right posterior temporal (r = 0.74, p < 0.01) cortices, Cerebral blood flow was not correlated with either mini-mental state examination scores or age, Conclusion: This preliminary study replicates the finding of hypofrontality inMDD and indicates that decreased perfusion is associated specificallywith negative symptom severity, These results support the hypothesis that, in MDD, negative symptoms and symptoms of depression are distinct phenomena and underscore the importance of negative symptom evaluation in neuroimaging studies of MDD and other disorders.

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Documento generato il 04/06/20 alle ore 00:07:32