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Titolo:
DUAL SPILLOVER PROBLEM IN THE MYOCARDIAL SEPTUM WITH NITROGEN-13-AMMONIA FLOW QUANTITATION
Autore:
HOVE JD; GAMBHIR SS; KOFOED KF; KELBAEK H; SCHELBERT HR; PHELPS ME;
Indirizzi:
UNIV CALIF LOS ANGELES,SCH MED,CRUMP INST BIOL IMAGING,DIV NUCL MED,DEPT MOL & MED PHARMACOL LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,SCH MED,CRUMP INST BIOL IMAGING,DIV NUCL MED,DEPT MOL & MED PHARMACOL LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,SCH MED,CRUMP INST BIOL IMAGING,DIV NUCL MED,DEPT BIOMATH LOS ANGELES CA 90095 RIGSHOSP,DIV CARDIOL,DEPT MED B,CTR HEART DK-2100 COPENHAGEN DENMARK
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 4, volume: 39, anno: 1998,
pagine: 591 - 598
SICI:
0161-5505(1998)39:4<591:DSPITM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BLOOD-FLOW; N-13 AMMONIA; NONINVASIVE QUANTIFICATION; PET; HUMANS; IMAGES; HEART;
Keywords:
PET; MYOCARDIAL BLOOD FLOW; SEPTUM; NITROGEN-13-AMMONIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Hove et al., "DUAL SPILLOVER PROBLEM IN THE MYOCARDIAL SEPTUM WITH NITROGEN-13-AMMONIA FLOW QUANTITATION", The Journal of nuclear medicine, 39(4), 1998, pp. 591-598

Abstract

Conventional cardiac PET modeling techniques for [N-13]ammonia flow determination do not fully account for the effects of spillover of activity from the right ventricle (RV) onto the activity in the myocardialseptum. The purpose of this study was to investigate and to quantitatively account and correct for this effect. Methods: Simulations were performed to determine the error introduced by conventional quantitation using septal time-activity curves, which only account for left ventricle (LV) spillover, Furthermore, we explored two separate methods to account for the dual spillover problem: direct estimation of the RV and LV spillover fractions incorporated into the [N-13]ammonia model by using the LV and RV input functions in the fit and estimation of the relative dispersion and time shift between the LV and RV input functions by fitting using only the LV input function. The simulated curves were fitted using a two-compartment [N-13]ammonia model. Flow estimates from the conventional model and the models including either of the twocorrection procedures were compared with canine microsphere data. Results: The influence of RV spillover on flow estimation in the septum is determined by several parameters (e.g., dispersion between the RV and LV input function). Depending on the value of these parameters, the septal flow may be underestimated by 0%-30%. The applied methods for correction of the dual spillover problem were comparable and allow for more accurate quantitation in the septum. The canine microsphere data revealed that flow underestimation in the septum is small but significant. Conclusion: Dual spillover in the myocardial septum can introducesignificant errors in the estimation of flow by the conventional [N-13]ammonia model fitting method, which does not properly account for the RV spillover. Adjusting for the RV spillover in one of the two proposed methods allows for more accurate quantitation of myocardial septalflow with [N-13]ammonia PET data.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:45:32