Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
UP-202-56, AN ADENOSINE ANALOG, SELECTIVELY ACTS VIA A(1) RECEPTORS TO SIGNIFICANTLY DECREASE NOXIOUSLY-EVOKED SPINAL C-FOS PROTEIN EXPRESSION
Autore:
HONORE P; BURITOVA J; CHAPMAN V; BESSON JM;
Indirizzi:
INSERM,U161,2 RUE ALESIA F-75014 PARIS FRANCE INSERM,U161 F-75014 PARIS FRANCE EPHE F-75014 PARIS FRANCE
Titolo Testata:
Pain
fascicolo: 2-3, volume: 75, anno: 1998,
pagine: 281 - 293
SICI:
0304-3959(1998)75:2-3<281:UAAASA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMEDIATE-EARLY GENES; DORSAL HORN NEURONS; ADENOSINE-A1-RECEPTORS MEDIATE; PHENYLISOPROPYL-ADENOSINE; CUTANEOUS HYPERALGESIA; SUBSTANTIA-GELATINOSA; INTRATHECAL INJECTION; LI NEURONS; L-PIA; RAT;
Keywords:
ADENOSINE ANALOG; A(1) RECEPTOR ANTAGONIST (DPCPX); A(2) RECEPTOR ANTAGONIST (DMPX); CARRAGEENAN INFLAMMATION; C-FOS PROTEIN EXPRESSION; DORSAL HEM; NOCICEPTION; UP 202-56;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
76
Recensione:
Indirizzi per estratti:
Citazione:
P. Honore et al., "UP-202-56, AN ADENOSINE ANALOG, SELECTIVELY ACTS VIA A(1) RECEPTORS TO SIGNIFICANTLY DECREASE NOXIOUSLY-EVOKED SPINAL C-FOS PROTEIN EXPRESSION", Pain, 75(2-3), 1998, pp. 281-293

Abstract

The effects of oral administration of UP 202-56, an adenosine analogue, were assessed on carrageenan-induced spinal c-Fos protein expression and peripheral oedema. Three hours after intraplantar injection of carrageenan (6 mg/150 mu l of saline), in awake rats, numerous c-Fos-like immunoreactive (c-Fos-LI) neurons in the dorsal horn of L4-L5 lumbar segments of the spinal cord (191 +/- 8; 184 +/- 10; 205 +/- 7 c-Fos-LI neurons per 40 mu m section, for carrageenan controls in three experimental series performed in this study, respectively) and an extensive peripheral oedema were observed. Oral UP 202-56 (10, 30 or 50 mg/kg)dose-dependently reduced the number of carrageenan-induced c-Fos-LI neurons (r = 0.931, P < 0.0001), with the highest dose of UP 202-56 producing 72 +/- 4% reduction of the total number of carrageenan-induced spinal c-Fos-LI neurons, and 12 +/- 3% and 33 +/- 6% of reduction of control carrageenan oedema at paw and ankle levels, respectively. DPCPX(1 mg/kg i.p.), a selective adenosine A(1) receptor antagonist, whichinjected alone had no effect on carrageenan-induced spinal c-Fos expression and peripheral oedema, blocked the effects of UP 202-56 (30 mg/kg p.o.) on the number of carrageenan-induced c-Fos-LI neurons. In addition, DPCPX did not modify the effects of UP 202-56 on carrageenan-induced peripheral oedema. DMPX (1 mg/kg i.p.), a somewhat selective adenosine A(2) receptor antagonist, which injected alone had no significant effect on carrageenan-induced spinal c-Fos protein expression and peripheral oedema, did not influence the effects of UP 202-56 (30 mg/kgp.o.) on both carrageenan-induced spinal c-Fos expression and peripheral oedema. Our results demonstrate that UP 202-56 dose-dependently reduced the spinal c-Fos protein expression in carrageenan model of inflammatory pain. The ability of DPCPX to block the effect of UP 202-56, in contrast to the lack of effect of DMPX, increased evidence for a predominant role of adenosine A(1) receptors activation in the mechanismof action of UP 202-56. These results increase evidence for a role ofadenosine in the modulation of nociceptive transmission and support the antinociceptive action of adenosine analogues, such as UP 202-56, in inflammatory pain processes. (C) 1998 International Association for the Study of Pain. Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 15:51:05