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Titolo:
TREATMENT OF CHRONIC ALLODYNIA IN SPINALLY INJURED RATS - EFFECTS OF INTRATHECAL SELECTIVE OPIOID RECEPTOR AGONISTS
Autore:
HAO JX; YU W; WIESENFELDHALLIN Z; XU XJ;
Indirizzi:
HUDDINGE UNIV HOSP,KAROLINSKA INST,DIV CLIN NEUROPHYSIOL,DEPT MED LABSCI & TECHNOL S-14186 HUDDINGE SWEDEN HUDDINGE UNIV HOSP,KAROLINSKA INST,DIV CLIN NEUROPHYSIOL,DEPT MED LABSCI & TECHNOL S-14186 HUDDINGE SWEDEN
Titolo Testata:
Pain
fascicolo: 2-3, volume: 75, anno: 1998,
pagine: 209 - 217
SICI:
0304-3959(1998)75:2-3<209:TOCAIS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL HORN NEURONS; C-FIBER REFLEX; NEUROPATHIC PAIN; CORD INJURY; ANIMAL-MODEL; NALTRINDOLE; MORPHINE; ANTINOCICEPTION; ANTAGONISTS; SYSTEMS;
Keywords:
CHRONIC PAIN; INTRATHECAL; MORPHINE; NEUROPATHIC PAIN; OPIOIDS; SPINAL CORD INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
J.X. Hao et al., "TREATMENT OF CHRONIC ALLODYNIA IN SPINALLY INJURED RATS - EFFECTS OF INTRATHECAL SELECTIVE OPIOID RECEPTOR AGONISTS", Pain, 75(2-3), 1998, pp. 209-217

Abstract

We examined the effects of intrathecal (i.t.) selective opioid receptor agonists in alleviating mechanical and cold allodynia in spinally injured rats. Both DAMGO ([D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin, a mu-opioid receptor agonist) and DPDPE ([D-Phe(2),D-Phe-(5)]-enkephalin, a delta-opioid receptor agonist) dose-dependently relieved the chronic allodynia-like behavior at doses selective for their respective receptors. The anti-allodynic effect of DAMGO and DPDPE was reversed bythe selective mu- and delta-opioid receptor antagonists CTOP (D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2) and naltrindole, respectively. In contrast, the selective kappa-opioid receptor agonist U50488H did not alleviate the allodynia-like behavior, but rather enhanced it. The anti-nociceptive and anti-allodynic effect of i.t. DAMGO was blocked by U50488H. Thus, activation of spinal mu- and delta-, but not kappa-opioid receptors produced anti-allodynic effect in this model of central pain. Drugs which act selectively on opioid receptor subtypes may be useful in managing chronic central pain of spinal cord origin. (C) 1998 International Association for the Study of Pain. Published by Elsevier Science B.V.

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Documento generato il 02/04/20 alle ore 11:57:51