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Titolo:
A CLOSE TEMPORAL RELATIONSHIP OF LIVER-DISEASE TO ANTIRIBOSOMAL P0 PROTEIN ANTIBODIES AND CENTRAL-NERVOUS-SYSTEM DISEASE IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
Autore:
YOSHIO T; MASUYAMA J; MINOTA S; KANEKO N; IWAMOTO M; OKAZAKI H; MIMORI A; TAKEDA A; KANO S;
Indirizzi:
JICHI MED SCH,DEPT MED,DIV CLIN IMMUNOL,3311 YAKUSHIJI MINAMI KAWACHITOCHIGI 32904 JAPAN
Titolo Testata:
Journal of rheumatology
fascicolo: 4, volume: 25, anno: 1998,
pagine: 681 - 688
SICI:
0315-162X(1998)25:4<681:ACTROL>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RIBOSOMAL-P; AUTOANTIBODIES; ASSOCIATION; PSYCHOSIS; MANIFESTATIONS; HEPATITIS;
Keywords:
LIVER DISEASE; ANTIRIBOSOMAL P PROTEIN ANTIBODIES; ANTIRIBOSOMAL P0 PROTEIN ANTIBODIES; CENTRAL NERVOUS SYSTEM LUPUS; SYSTEMIC LUPUS ERYTHEMATOSUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
T. Yoshio et al., "A CLOSE TEMPORAL RELATIONSHIP OF LIVER-DISEASE TO ANTIRIBOSOMAL P0 PROTEIN ANTIBODIES AND CENTRAL-NERVOUS-SYSTEM DISEASE IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS", Journal of rheumatology, 25(4), 1998, pp. 681-688

Abstract

Objective, To determine whether there is a close temporal relationship of liver disease to serum IgG and/or IgM antiribosomal PO protein antibodies (anti-PO) and central nervous system (CNS) lupus in patients with systemic lupus erythematosus (SLE). Methods. The study included 70 patients with active SLE. Of these, 30 had IgG and/or IgM anti-PO and 14 had CNS lupus other than psychiatric disease (nonpsychiatric CNS lupus). Of these 14 patients, 11 had anti-PO. Laboratory manifestations of liver disease were retrospectively analyzed. Results, Liver disease not attributed to any cause other than SLE (SLE liver disease) was present in 8 of the 11 patients with anti-PO with nonpsychiatric CNS lupus (72.7%), in none of the 19 patients with anti-PO without nonpsychiatric CNS lupus (0%), and in one of the 40 patients without anti-PO (2.5%). The prevalence of SLE liver disease was significantly greater in patients with anti-PO with nonpsychiatric CNS lupus than in the other 2 groups (p < 0.0001). Mean levels of liver enzymes (lactate dehydrogenase, glutamic oxaloacetic transaminase, glutamate pyruvate transaminase, gamma-glutamyl transpeptidase) were significantly higher in patients with anti-PO with nonpsychiatric CNS lupus than in the other 2 groups. Serial studies in 3 patients showed that the appearance of anti-PO and liver dysfunction slightly preceded the onset of nonpsychiatricCNS lupus. Conclusion, Anti-PO may be related to the pathogenesis of CNS lupus and SLE liver disease found simultaneously in SLE. The appearance of anti-PO and liver dysfunction may predict onset of CNS lupus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:34:41