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Titolo:
ENHANCED SENSITIVITY OF MEDULLARY DEPRESSOR NEURONS TO N-METHYL-D-ASPARTATE-GLYCINE SITE ANTAGONISTS IN THE SPONTANEOUSLY HYPERTENSIVE RAT
Autore:
KAPOOR R; KAPOOR V;
Indirizzi:
UNIV NEW S WALES,SCH PHYSIOL & PHARMACOL SYDNEY NSW 2052 AUSTRALIA UNIV NEW S WALES,SCH PHYSIOL & PHARMACOL SYDNEY NSW 2052 AUSTRALIA
Titolo Testata:
Clinical and experimental pharmacology and physiology
fascicolo: 3-4, volume: 25, anno: 1998,
pagine: 216 - 219
SICI:
0305-1870(1998)25:3-4<216:ESOMDN>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAUDAL VENTROLATERAL MEDULLA; BLOOD-PRESSURE REGULATION; KYNURENIC ACID; NMDA RECEPTOR; D-SERINE; L-GLUTAMATE; BRAIN-STEM; SHR; STIMULATION; MOUSE;
Keywords:
BLOOD PRESSURE; CAUDAL VENTROLATERAL MEDULLA; 5-FLUORO INDOLE-2-CARBOXYLIC ACID; KYNURENIC ACID; N-METHYL-D-ASPARTATE ANTAGONIST; N-METHYL-D-ASPARTATE RECEPTORS; SPONTANEOUSLY HYPERTENSIVE RAT; STRYCHNINE-INSENSITIVE GLYCINE MODULATORY SITE; WISTAR-KYOTO RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
R. Kapoor e V. Kapoor, "ENHANCED SENSITIVITY OF MEDULLARY DEPRESSOR NEURONS TO N-METHYL-D-ASPARTATE-GLYCINE SITE ANTAGONISTS IN THE SPONTANEOUSLY HYPERTENSIVE RAT", Clinical and experimental pharmacology and physiology, 25(3-4), 1998, pp. 216-219

Abstract

1. The effects of the specific N-methyl-D-aspartate (NMDA)-glycine site antagonist 5-fluoro indole-2-carboxylic acid (FICA) and NMDA, microinjected into the vasodepressor caudal ventrolateral medulla, were compared in spontaneously hypertensive rats (SHR) and in Wistar-Kyoto (WKY) rats, 2. 5-Fluoro indole-2-carboxylic acid elicited a significant presser response (+20.0+4.9 mmHg) in SHR, but no change was found in the basal blood pressure of WKY rats, 3. The depressor response due to NMDA microinjection was significantly larger in SHR (-48.0+/-4 mmHg) than in WKY rats (-23.0+/-1.9 mmHg), 4. Pre-injection of FICA attenuatedthe depressor effects of NMDA significantly, this blockade being significantly more pronounced in SHR (37.0+/-2.7 mmHg) than in WKY rats (12.0+/-1.2 mmHg), 5. The enhanced responses to PICA may reflect the lower levels of the endogenous NMDA-glycine antagonist kynurenic acid in SHR compared with WKY rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:54:42