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Titolo:
THE DISCOIDIN DOMAIN RECEPTOR TYROSINE KINASES ARE ACTIVATED BY COLLAGEN
Autore:
VOGEL W; GISH GD; ALVES F; PAWSON T;
Indirizzi:
MT SINAI HOSP,SAMUEL LUNENFELD RES INST,PROGRAMME MOL BIOL CANC,600 UNIV AVE TORONTO ON M5G 1X5 CANADA MT SINAI HOSP,SAMUEL LUNENFELD RES INST,PROGRAMME MOL BIOL CANC TORONTO ON M5G 1X5 CANADA UNIV KLIN GOTTINGEN,DEPT HEMATOL & ONCOL D-37075 GOTTINGEN GERMANY UNIV TORONTO,DEPT MOL & MED GENET TORONTO ON M5S 1A8 CANADA
Titolo Testata:
MOLECULAR CELL
fascicolo: 1, volume: 1, anno: 1997,
pagine: 13 - 23
SICI:
1097-2765(1997)1:1<13:TDDRTK>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DICTYOSTELIUM-DISCOIDEUM; PROTEIN; BINDING; IDENTIFICATION; EXPRESSION; CANCER; TUMOR; PHOSPHOTYROSINE; INDUCTION; SEQUENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
W. Vogel et al., "THE DISCOIDIN DOMAIN RECEPTOR TYROSINE KINASES ARE ACTIVATED BY COLLAGEN", MOLECULAR CELL, 1(1), 1997, pp. 13-23

Abstract

Two mammalian receptor tyrosine kinases (DDR1 and DDR2) have extracellular domains closely related to a D. discoideum lectin, discoidin, required for cell aggregation. Here, we show that the mammalian DDR receptors bind and are activated by specific types of collagen. Stimulation of DDR receptor tyrosine kinase activity requires the native triple-helical structure of collagen and occurs over an extended period of time. Collagen activation of DDR1 induces phosphorylation of a docking site for the Shc phosphotyrosine binding domain, whose presence is controlled by alternative splicing. Activation of DDR2 by collagen resultsin the up-regulation of matrix metalloproteinase-l expression. These results suggest that the discoidin-related DDR tyrosine kinases are novel collagen receptors with the potential to control cellular responses to the extracellular matrix.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:01:44