Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
FUNCTIONAL EVIDENCE THAT BDNF IS AN ANTEROGRADE NEURONAL TROPHIC FACTOR IN THE CNS
Autore:
FAWCETT JP; BAMJI SX; CAUSING CG; ALOYZ R; ASE AR; READER TA; MCLEAN JH; MILLER FD;
Indirizzi:
MCGILL UNIV,MONTREAL NEUROL INST,CTR NEURONAL SURVIVAL,3801 UNIV ST MONTREAL PQ H3A 2B4 CANADA MCGILL UNIV,MONTREAL NEUROL INST,CTR NEURONAL SURVIVAL MONTREAL PQ H3A 2B4 CANADA UNIV MONTREAL,CTR RECH SCI NEUROL MONTREAL PQ H3C 3J7 CANADA MEM UNIV NEWFOUNDLAND,DIV BASIC MED SCI ST JOHNS NF A1B 3V6 CANADA
Titolo Testata:
The Journal of neuroscience
fascicolo: 8, volume: 18, anno: 1998,
pagine: 2808 - 2821
SICI:
0270-6474(1998)18:8<2808:FETBIA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-BETA-HYDROXYLASE; RAT CEREBRAL-CORTEX; NERVE GROWTH-FACTOR; NEUROTROPHIC FACTOR; LOCUS COERULEUS; POSTNATAL-DEVELOPMENT; VISUAL-SYSTEM; BRAIN; EXPRESSION; NUCLEUS;
Keywords:
BDNF; NORADRENERGIC NEURONS; ANTEROGRADE NEUROTROPHIC FACTORS; CEREBRAL CORTEX; MOTOR NEURONS; NEURONAL REGENERATION; NEURONAL DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
J.P. Fawcett et al., "FUNCTIONAL EVIDENCE THAT BDNF IS AN ANTEROGRADE NEURONAL TROPHIC FACTOR IN THE CNS", The Journal of neuroscience, 18(8), 1998, pp. 2808-2821

Abstract

In this report, we have tested the hypothesis that brain-derived neurotrophic factor (BDNF) is an anterograde neurotrophic factor in the CNS and have focused on central noradrenergic neurons that synthesize BDNF. Double-label immunocytochemistry for BDNF and dopamine-beta-hydroxylase (DBH), a marker for noradrenergic neurons, demonstrated that BDNF is partially localized to noradrenergic nerve fibers and terminals in the adult rat brain. To test the functional importance of this anterograde BDNF, we analyzed transgenic mice carrying a DBH-BDNF minigene. Increased synthesis of BDNF in noradrenergic neurons of DBH-BDNF micecaused elevated TrkB tyrosine kinase activation throughout postnatal life in the neocortex, a noradrenergic target region. This afferently regulated increase in TrkB receptor activity led to long-lasting alterations in cortical morphology. To determine whether noradrenergic neuron-expressed BDNF also anterogradely regulated neuronal survival, we examined a second noradrenergic target, neonatal facial motoneurons. One week after axotomy, 72% of facial motoneurons were lost in control animals, whereas only 30-35% were lost in DBH-BDNF transgenic mice. Altogether, these results indicate that BDNF is anterogradely transportedto fibers and terminals of noradrenergic neurons, that anterogradely secreted BDNF causes activation of TrkB in target regions, and that this secretion has functional consequences for target neuron survival and differentiation. This presynaptic secretion of BDNF may provide a cellular mechanism for modulating neural circuitry, in either the developing or mature nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 08:18:30