Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RECEPTOR-SPECIFIC INDUCTION OF NF-KAPPA-B COMPONENTS IN PRIMARY B-CELLS
Autore:
FRANCIS DA; SEN RJ; RICE N; ROTHSTEIN TL;
Indirizzi:
BOSTON UNIV,MED CTR,DEPT MED & MICROBIOL,ROOM E-556,88 E NEWTON ST BOSTON MA 02118 BOSTON UNIV,MED CTR,DEPT MED & MICROBIOL BOSTON MA 02118 BOSTON UNIV,MED CTR,DEPT PATHOL BOSTON MA 02118 BOSTON UNIV,MED CTR,EVANS MEM DEPT CLIN RES BOSTON MA 02118 BRANDEIS UNIV,DEPT BIOL,ROSENSTIEL CTR WALTHAM MA 02254 NCI,FREDERICK CANC RES & DEV CTR,BASIC RES PROGRAM FREDERICK MD 00000
Titolo Testata:
International immunology
fascicolo: 3, volume: 10, anno: 1998,
pagine: 285 - 293
SICI:
0953-8178(1998)10:3<285:RIONCI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
UBIQUITIN-PROTEASOME PATHWAY; TRANSCRIPTION FACTOR; NUCLEAR EXPRESSION; DNA-BINDING; PRECURSOR P105; B/REL FAMILY; ACTIVATION; RELB; PROTEINS; STIMULATION;
Keywords:
B CELL ANTIGEN RECEPTOR; B LYMPHOCYTES; CD40 RECEPTOR; DNA-BINDING PROTEINS; I-KAPPA-B PROTEINS; RELB PROTEIN; TRANSCRIPTION FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Francis et al., "RECEPTOR-SPECIFIC INDUCTION OF NF-KAPPA-B COMPONENTS IN PRIMARY B-CELLS", International immunology, 10(3), 1998, pp. 285-293

Abstract

The NF-kappa B transcription factor complex plays a key role in the expression of genes involved in immune responses. Nuclear NF-kappa B isinduced in B lymphocytes by engagement of either the antigen receptor(sig) or the CD40 receptor for a T cell activation antigen, although different intracellular pathways appear to be involved. In the presentstudy the protein composition of NF-kappa B complexes triggered by sig and CD40 was probed by electrophoretic mobility shift, supershift, shift-Western, and Western blot analyses. At the time of peak NF-kappa B induction (2 h), the NF-kappa B components detected in the complexesinduced through sig and through CD40 were the same. However, with continued stimulation RelB completely disappeared from anti-Ig-stimulatedkappa B binding material, but remained a component of CD40L-induced NF-kappa B. The toss of DNA-binding RelB from anti-Ig-induced NF-kappa B did not result from depletion of RelB from B cell nuclei, suggestingspecific regulation of RelB function which is not directly attributedto I kappa B function. These results indicate that NF-kappa B complexes may undergo protein-specific alterations in a time- and receptor-dependent fashion that may be associated with differences in the outcomes of B cell stimulation through sig and CD40.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:58:52