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Titolo:
CORRELATES AND PREVALENCE OF BENZODIAZEPINE USE IN COMMUNITY-DWELLINGELDERLY
Autore:
GLEASON PP; SCHULZ R; SMITH NL; NEWSOM JT; KROBOTH P; KROBOTH FJ; PSATY BM;
Indirizzi:
UNIV PITTSBURGH,SCH PHARM,DEPT PHARMACEUT SCI,904 SALK HALL PITTSBURGH PA 15261
Titolo Testata:
Journal of general internal medicine
fascicolo: 4, volume: 13, anno: 1998,
pagine: 243 - 250
SICI:
0884-8734(1998)13:4<243:CAPOBU>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELIMINATION HALF-LIFE; PSYCHOTROPIC-DRUG USE; HIP FRACTURE; RISK; PHARMACOKINETICS; THERAPY; ANXIETY; TERM; LONG; PHARMACODYNAMICS;
Keywords:
BENZODIAZEPINE; SLEEP AID MEDICATION, OVER-THE-COUNTER; CARDIOVASCULAR HEALTH STUDY; ELDERLY; ANXIOLYTICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
P.P. Gleason et al., "CORRELATES AND PREVALENCE OF BENZODIAZEPINE USE IN COMMUNITY-DWELLINGELDERLY", Journal of general internal medicine, 13(4), 1998, pp. 243-250

Abstract

OBJECTIVE: To describe the prevalence of benzodiazepine use, sociodemographic and physical health factors associated with use, dosages taken, and directions for use among individuals aged 65 years and older. DESIGN: Cross-sectional analysis of baseline data from the community-based, prospective observational Cardiovascular Health Study. PATIENTS/PARTICIPANTS: Medicare eligibility Lists from four U.S. communities were used to recruit a representative sample of 5,201 community-dwelling elderly, of which 5,181 participants met all study criteria. MEASUREMENTS AND MAIN RESULTS: Among participants, 511 (9.9%) were taking at least one benzodiazepine, primarily anxiolytics (73%). Benzodiazepines were often prescribed to be taken pro re nata (PRN ''as needed''), and 36.5% of prescriptions with instructions to he taken regularly were taken at a dose lower than prescribed. Reported over-the-counter (OTC) sleep aid medication use was 39.2% in benzodiazepine users and 3.3% in nonusers. In a multivariate logistic model, the significant independent correlates of benzodiazepine use were being white (odds ratio [OR] 1.9; 95% confidence interval [CI] 1.0, 3.4), female (OR 1.7; CI 1.4, 2.2), and living in Forsyth County, North Carolina, or Washington County, Maryland, compared with living in Sacramento County, California, or Allegheny County, Pennsylvania (OR 2.3; CI 1.4, 2.2); having coronary heart disease (OR 1.6; CI 1.2, 2.1), health status reported as poor orfair (OR 1.8; CI 1.4, 2.3), self-reported diagnosis of nervous or emotional disorder (OR 6.7; CI 5.1, 8.7), and reporting use of an OTC sleep aid medication (OR 18.7; CI 14.1, 24.7). CONCLUSIONS: One in 10 participants reported taking a benzodiazepine, most frequently an anxiolytic, often at a lower dose than prescribed and usually PRN. The high prevalence of OTC sleep aid medication and benzodiazepine use may placethe patient at increased risk of psychomotor impairment. Physicians should assess OTC sleep aid medication use when prescribing benzodiazepines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:26:25