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Titolo:
BETA-NAPHTHOFLAVONE ABOLISHES INTERRENAL SENSITIVITY TO ACTH STIMULATION IN RAINBOW-TROUT
Autore:
WILSON JM; VIJAYAN MM; KENNEDY CJ; IWAMA GK; MOON TW;
Indirizzi:
UNIV BRITISH COLUMBIA,DEPT ANIM SCI,208-2357 MAIN MALL VANCOUVER BC V6T 1Z4 CANADA UNIV BRITISH COLUMBIA,DEPT ANIM SCI VANCOUVER BC V6T 1Z4 CANADA UNIV BRITISH COLUMBIA,CANADIAN BACTERIAL DIS NETWORK VANCOUVER BC V6T1Z4 CANADA SIMON FRASER UNIV,DEPT BIOL SCI BURNABY BC V5A 1S6 CANADA UNIV OTTAWA,DEPT BIOL OTTAWA ON CANADA
Titolo Testata:
Journal of Endocrinology
fascicolo: 1, volume: 157, anno: 1998,
pagine: 63 - 70
SICI:
0022-0795(1998)157:1<63:BAISTA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ONCORHYNCHUS-MYKISS; HEPATOCYTE METABOLISM; CORTISOL; FISH; SECRETION; ENZYMES; TELEOST; INJECTION; TISSUES; STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Wilson et al., "BETA-NAPHTHOFLAVONE ABOLISHES INTERRENAL SENSITIVITY TO ACTH STIMULATION IN RAINBOW-TROUT", Journal of Endocrinology, 157(1), 1998, pp. 63-70

Abstract

We report for the first time that beta-naphthoflavone (BNF) abolishesACTH stimulation of cortisol production in rainbow trout (Oncorhynchus mykiss). There was significantly higher hepatic cytochrome P450 content and ethoxyresorufin O-de-ethylase and uridine-5'-diphosphoglucuronic acid transferase activities in BNF-treated fish than in sham-treated controls. BNF did not significantly effect either plasma turnover ortissue distribution of [H-3]cortisol-derived radioactivity. Hepatic membrane fluidity and hepatocyte capacity for cortisol uptake were not altered by BNF as compared with the sham-treated fish. These results taken together suggest that BNF does not affect cortisol-clearance mechanisms in trout. A 3 min handling disturbance period elicited a plasmacortisol response in the sham-treated fish; however, the response in the BNF-treated fish was muted and significantly lower than in the sham fish. This in vivo response corroborates the lack of interrenal sensitivity to ACTH in vitro in the BNF-treated fish, suggesting that BNF affects the ACTH pathway in trout. Our results suggest the possibilitythat cytochrome P450-inducing compounds may affect cortisol dynamics by decreasing interrenal responsiveness to ACTH stimulation in fish, thereby impairing the physiological responses that are necessary for the animal to cope with the stressor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 10:22:29