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Titolo:
GROWTH-PROPERTIES AND GROWTH-FACTOR RESPONSIVENESS IN SKIN FIBROBLASTS FROM CENTENARIANS
Autore:
TESCO G; VERGELLI M; GRASSILLI E; SALOMONI P; BELLESIA E; SIKORA E; RADZISZEWSKA E; BARBIERI D; LATORRACA S; FAGIOLO U; SANTACATERINA S; AMADUCCI L; TIOZZO R; FRANCESCHI C; SORBI S;
Indirizzi:
HARVARD UNIV,SCH MED,MGH,GENET & AGING UNIT,139 13TH ST CHARLESTOWN MA 02139 UNIV FLORENCE,DEPT NEUROL & PSYCHIAT SCI FLORENCE ITALY UNIV PADUA,INST INTERNAL MED PADUA ITALY M NENCKI INST EXPT BIOL PL-02093 WARSAW POLAND UNIV MODENA,DEPT BIOMED SCI I-41100 MODENA ITALY
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 3, volume: 244, anno: 1998,
pagine: 912 - 916
SICI:
0006-291X(1998)244:3<912:GAGRIS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN LONGEVITY; INVITRO; CELLS; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
G. Tesco et al., "GROWTH-PROPERTIES AND GROWTH-FACTOR RESPONSIVENESS IN SKIN FIBROBLASTS FROM CENTENARIANS", Biochemical and biophysical research communications, 244(3), 1998, pp. 912-916

Abstract

Human fibroblast cultures, which have a finite replicative lifespan in vitro, are the most widely used model for the study of senescence atthe cellular level. An inverse relationship between replicative capability and donor age has been reported in human fibroblast strains. We studied the growth capacity of fibroblast primary cultures derived from people whose lifespan was as closer as possible to the expected maximum human lifespan, i.e. people over one hundred. Our data suggest that outgrowth of fibroblasts from biopsies, growth kinetics at differentpopulation doubling levels, capability to respond to a classical mitogenic stimulus (such as 20% serum) and a variety of growth factors, were remarkably similar in fibroblasts from centenarians and young controls. On the whole, our data challenge the tenet of a simple and strictrelationship between in vivo aging and in vitro proliferative capability of human fibroblasts, at least at the individual level. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 05:53:59