Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE IN-VITRO EFFECT OF RIDOGREL ON PLATELET-FUNCTION IN NORMOCHOLESTEROLEMIC AND FAMILIAL HYPERCHOLESTEROLEMIC TYPE IIA SUBJECTS
Autore:
NARAN NH; CHETTY N;
Indirizzi:
S AFRICAN INST MED RES,DEPT HAEMATOL,SCH PATHOL,POB 1038 ZA-2000 JOHANNESBURG GAUTENG SOUTH AFRICA S AFRICAN INST MED RES,DEPT HAEMATOL,SCH PATHOL ZA-2000 JOHANNESBURG GAUTENG SOUTH AFRICA UNIV WITWATERSRAND ZA-2000 JOHANNESBURG GAUTENG SOUTH AFRICA
Titolo Testata:
Thrombosis research
fascicolo: 5, volume: 88, anno: 1997,
pagine: 399 - 407
SICI:
0049-3848(1997)88:5<399:TIEORO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
THROMBOXANE-A2 SYNTHETASE INHIBITION; RECEPTOR GENE-MUTATIONS; SYNTHASE INHIBITOR; ONE MOLECULE; HYPERBETALIPOPROTEINEMIA; HYPERLIPOPROTEINEMIA; HYPERSENSITIVITY; CHOLESTEROL; ANTAGONIST; PROBUCOL;
Keywords:
RIDOGREL; PLATELET FUNCTION; HYPERCHOLESTEROLEMIA; THROMBOXANE; CAMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
N.H. Naran e N. Chetty, "THE IN-VITRO EFFECT OF RIDOGREL ON PLATELET-FUNCTION IN NORMOCHOLESTEROLEMIC AND FAMILIAL HYPERCHOLESTEROLEMIC TYPE IIA SUBJECTS", Thrombosis research, 88(5), 1997, pp. 399-407

Abstract

Platelets from familial hypercholesterolaemia type IIa patients are hyperreactive and produce increased amounts of thromboxane A(2). These modifications of platelet function may play an important role in the occurrence of premature atherosclerosis. One approach to the preventionof the thromboembolic complications of atherosclerosis is the use of antiplatelet agents which depress platelet function. Ridogrel, a combined thromboxane synthase inhibitor and thromboxane A(2)/prostaglandin endoperoxide receptor blocker inhibits platelet aggregation, This study was designed to investigate the in vitro effect of ridogrel on platelet function in normocholesterolaemic and familial hypercholesterolaemia type IIa subjects, In citrated platelet rich plasma ridogrel significantly inhibited platelet aggregation and thromboxane A(2) productionin response to collagen, ADP and arachidonic acid stimulation. In washed platelets ridogrel significantly decreased aggregation and serotonin release, Ridogrel significantly increased cAMP levels in response to thrombin stimulation. In conclusion, ridogrel at low concentrations significantly inhibited the in vitro function of platelets in a dose dependant manner in both normocholesterolaemic subjects and familial hypercholesterolaemia IIa subjects. (C) 1998 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:34:25