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Titolo:
ACUTE 2,4-DICHLOROPHENOXYACETIC ACID INTOXICATION IN BROILER CHICKS
Autore:
MORGULIS MSFA; OLIVEIRA GH; DAGLI MLZ; PALERMONETO J;
Indirizzi:
UNIV SAO PAULO,SCH VET MED,DEPT PATHOL,RES CTR VET TOXICOL,CEPTOX BR-05508900 SAO PAULO BRAZIL UNIV SAO PAULO,SCH VET MED,DEPT PATHOL,RES CTR VET TOXICOL,CEPTOX BR-05508900 SAO PAULO BRAZIL UNESP,SCH PHARMACEUT SCI,DEPT NAT ACT PRINCIPLES ARARAQUARA SP BRAZIL
Titolo Testata:
Poultry science
fascicolo: 4, volume: 77, anno: 1998,
pagine: 509 - 515
SICI:
0032-5791(1998)77:4<509:A2AIIB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENZYME-ACTIVITIES; SERUM COMPONENTS; 2,4-D; CATTLE; RAT;
Keywords:
2,4-DICHLOROPHENOXYACETIC ACID; HERBICIDE; INTOXICATION; BROILER; PESTICIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
M.S.F.A. Morgulis et al., "ACUTE 2,4-DICHLOROPHENOXYACETIC ACID INTOXICATION IN BROILER CHICKS", Poultry science, 77(4), 1998, pp. 509-515

Abstract

The acute toxicity of 2,4-dichlorophenoxyacetic acid (2,4-D), a herbicide, was studied in chicks dosed with 100, 300, 500, or 600 mg 2,4-D/kg BW, by the oral route. Clinical, laboratory, and histopathological methods were used as indicators of toxicity. After acute exposure, theherbicide decreased motor activity and induced muscular weakness and motor incoordination; decreased weight gain; increased serum creatine kinase (CK) and alkaline phosphatase (AP) activities and serum uric acid (UA), creatinine (CR), and total proteins (TP) levels; and did not change serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) activities. These changes were time-and dose-dependent and reversible. The LD50 (lethal dose 50%) calculated for oral 2,4-D in chicks was 420 mg/kg BW (385 to 483). Chromatographic analysis of the serum of the intoxicated chicks showed the presence of the herbicide; theamount found was dose-and time-dependent, increasing from 2 to 8 h after exposure and decreasing afterwards. Histopathological post-mortem studies conducted on intoxicated chicks showed hepatic (vacuolar degeneration of the hepatocytes), renal (tubular nephrosis), and intestinal(hemorragic) lesions. Taken together, the observed alterations mainlyreflected kidney and muscle tissue damage, although hepatic toxicity may also have occurred after acute 2,4-D intoxication.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/06/20 alle ore 07:45:22