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Titolo:
BROAD IMMUNOCYTOCHEMICAL LOCALIZATION OF THE FORMYLPEPTIDE RECEPTOR IN HUMAN ORGANS, TISSUES, AND CELLS
Autore:
BECKER EL; FOROUHAR FA; GRUNNET ML; BOULAY F; TARDIF M; BORMANN BJ; SODJA D; YE RD; WOSKA JR; MURPHY PM;
Indirizzi:
UNIV CONNECTICUT,CTR HLTH,DEPT PATHOL,263 FARMINGTON AVE FARMINGTON CT 06030 CEA,BIOCHIM LAB,CNRS,URA 1130,DBMS F-38054 GRENOBLE 9 FRANCE PFIZER INC,CENT RES,RES & DEV GROTON CT 06340 SCRIPPS CLIN & RES INST,DEPT IMMUNOL LA JOLLA CA 92037 BOEHRINGER INGELHEIM PHARMACEUT INC,DEPT IMMUNOL RIDGEFIELD CT 06877 NIAID,HOST DEF LAB,NIH BETHESDA MD 20892
Titolo Testata:
Cell and tissue research
fascicolo: 1, volume: 292, anno: 1998,
pagine: 129 - 135
SICI:
0302-766X(1998)292:1<129:BILOTF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORMYL PEPTIDE RECEPTOR; N-FORMYLPEPTIDE; CHEMOTACTIC FACTORS; HUMAN-SPERMATOZOA; LIGAND-BINDING; CDNA; NEUTROPHILS; IDENTIFICATION;
Keywords:
NEURONS; BRAIN; CHEMOTAXIS; ENDOTHELIAL CELLS; HUMAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
E.L. Becker et al., "BROAD IMMUNOCYTOCHEMICAL LOCALIZATION OF THE FORMYLPEPTIDE RECEPTOR IN HUMAN ORGANS, TISSUES, AND CELLS", Cell and tissue research, 292(1), 1998, pp. 129-135

Abstract

The formylpeptide receptor (FPR), previously found only on polymorphonuclear leukocytes and monocytes/macrophages, responds to both synthetic N-formyl oligopeptides and those produced by bacteria. The cDNA forhuman FPR has been cloned and a rabbit polyclonal antiserum directed against a synthetic 11-amino-acid peptide corresponding to the deducedcarboxy-terminus has been produced. We have now extensively characterized and used the antibody to detect FPR on normal human tissues and cell types. The receptor antigen is present on some epithelial cells, especially those with a secretory function, and on some endocrine cells, e,g., follicular cells of the thyroid and cortical cells of the adrenal. Liver hepatocytes and Kupffer cells are positive. Smooth muscle and endothelial cells are also generally positive. In the brain and spinal cord, the neurons of the motor, sensory, and cerebellar systems, and those of the parasympathetic and sympathetic systems stain positively. These data suggest that the putative endogenous agonist for FPR oran antigenically similar receptor reacts with cellular targets in theneuromuscular, vascular, endocrine, and immune systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 17:50:13