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Titolo:
CIS-DIAMINEDICHLOROPLATINUM(II) COMPLEXES REVERSIBLY LINKED INTO THE MAIN-CHAIN OF WATER-SOLUBLE POLYAMIDES
Autore:
NEUSE EW; CALDWELL G;
Indirizzi:
UNIV WITWATERSRAND,DEPT CHEM ZA-2050 WITWATERSRAND SOUTH AFRICA
Titolo Testata:
Journal of inorganic and organometallic polymers
fascicolo: 3, volume: 7, anno: 1997,
pagine: 163 - 181
SICI:
1053-0495(1997)7:3<163:CCRLIT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTENTIAL-DRUG CARRIERS; BIOMEDICAL APPLICATIONS; INTRACHAIN-TYPE; POLYMERS; POLYAMIDOAMINES; POLYMERIZATION; LIGANDS;
Keywords:
CIS-DIAMINEDICHLOROPLATINUM(II); POLYAMIDE CARRIERS; MAIN-CHAIN PLATINATION; WATER-SOLUBILITY;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
E.W. Neuse e G. Caldwell, "CIS-DIAMINEDICHLOROPLATINUM(II) COMPLEXES REVERSIBLY LINKED INTO THE MAIN-CHAIN OF WATER-SOLUBLE POLYAMIDES", Journal of inorganic and organometallic polymers, 7(3), 1997, pp. 163-181

Abstract

As a follow-up study to previous work involving the platination of polyamide carriers through metal chelation by side group-incorporated ethylenediamine ligands, the present investigation is concerned with thesynthesis of platinum-containing polymers in which the metal-coordinating ethylenediamine segments are components of the main chain. Two chloro groups in cia geometry are attached to each Pt atom as additionalligands, complementing a square-planar cis-diaminedichloroplatinum(Il) complex system. The water-soluble polymeric carriers are synthesizedby Michael-type addition polymerization, interfacial polymerization, and high-temperature solution polycondensation techniques and are crudely fractionated by stepwise aqueous dialysis, ultimately in tubing with a molecular mass cutoff of 25,000. Carrier platination is brought about by treatment with tetrachloroplatinate(II) anion in aqueous solution, care being taken to exercise strict control of reaction variablesand workup conditions in an effort to restrict platination to the given ligands and avoid metal aquation or hydroxylation. The platinum conjugates, with Pt contents ranging from about 11 to 23% by mass, are completely soluble in aqueous media when freshly prepared, although long-term storage at room temperature in the solid state is conducive to gradual loss of solubility. The conjugates are of interest as carcinostatic agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 02:57:40