Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECT OF MILD HYPOTHERMIA AND THE 21-AMINOSTEROID U-74389G ON NEUROLOGIC AND HISTOPATHOLOGIC OUTCOME AFTER TRANSIENT SPINAL-CORD ISCHEMIA IN THE RABBIT
Autore:
DEHAAN P; KALKMAN CJ; VANICKY I; JACOBS MJHM; DRUMMOND JC;
Indirizzi:
UNIV AMSTERDAM,ACAD MED CTR,ACAD HOSP,DEPT ANESTHESIOL,MEIBERGDREEF 9NL-1105 AZ AMSTERDAM NETHERLANDS UNIV AMSTERDAM,ACAD HOSP,DEPT ANESTHESIOL NL-1105 AZ AMSTERDAM NETHERLANDS UNIV AMSTERDAM,ACAD HOSP,DEPT VASC SURG NL-1105 AZ AMSTERDAM NETHERLANDS SLOVAK ACAD SCI,INST NEUROBIOL KOSICE 04001 SLOVAKIA UNIV CALIF SAN DIEGO,VET ADM MED CTR,DEPT ANESTHESIOL SAN DIEGO CA 92161
Titolo Testata:
Journal of neurosurgical anesthesiology
fascicolo: 2, volume: 10, anno: 1998,
pagine: 86 - 93
SICI:
0898-4921(1998)10:2<86:EOMHAT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE NEUROTOXICITY; BRAIN TEMPERATURE; FLUID DRAINAGE; NITRIC-OXIDE; RAT-BRAIN; INJURY; DAMAGE; REPERFUSION; PROTECTION; TIRILAZAD;
Keywords:
SPINAL CORD ISCHEMIA; MILD HYPOTHERMIA; 21-AMINOSTEROID; LAZAROID; U-74389G; RABBIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
P. Dehaan et al., "EFFECT OF MILD HYPOTHERMIA AND THE 21-AMINOSTEROID U-74389G ON NEUROLOGIC AND HISTOPATHOLOGIC OUTCOME AFTER TRANSIENT SPINAL-CORD ISCHEMIA IN THE RABBIT", Journal of neurosurgical anesthesiology, 10(2), 1998, pp. 86-93

Abstract

Mild hypothermia and the 21-aminosteroids have both been neuroprotective In several models of cerebral ischemia. In this study we compared the effects of mild hypothermia and the 21-aminosteroid U-74389G, alone and in combination on neurologic and histopathologic outcome after temporary spinal cord ischemia. Ferry male anaesthetized New Zealand white rabbits were randomized to four groups (n = 10): (a) normothermia (control); (b) U-74389G (3 mg/kg intravenously [i.v.] before aortic occlusion, 1.5 mg/kg i.v. and 10 mg/kg intraperitoneally after occlusion); (c) mild hypothermia (4 degrees C epidural temperature decrease); and (d) mild hypothermia combined with U-74389G. Spinal cord ischemia was produced by 40 min of infrarenal aortic balloon occlusion. Forty-eight hours after the procedure, the neurologic status of the animals was assessed (Tarlov score) and the animals were killed for histologic evaluation. In the normothermic control group, eight of 10 animals became paraplegic. There was a significant reduction of the incidence of paraplegia and overall neurologic deficits and a significant improved Tarlov score in the mild hypothermic group (one animal paraplegic) and in the group with both mild hypothermia and U-74389G (two animals witha mild paraparesis). The histopathologic scares showed significantly less damage in both hypothermic groups. In group 2, U-74389G administration did not improve neurologic or histopathologic outcomes. The results of the current study demonstrate that a slight decrease of intraischemic spinal cord temperature significantly improved neurologic and histopathologic outcomes after experimental spinal cord ischemia. Protection by the 21-aminosteroid at normothermic conditions, or additionalprotection when U-74389G was added to mild hypothermia, could not be demonstrated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:44:41