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Titolo:
TRANSCRIPTION FACTORS THAT REGULATE MONOCYTE MACROPHAGE DIFFERENTIATION/
Autore:
VALLEDOR AF; BORRAS FE; CULLELLYOUNG M; CELADA A;
Indirizzi:
UNIV BARCELONA,FAC BIOL,DEPT FISIOL IMMUNOL,AV DIAGONAL,645,3A PLANTA,CAMPUS DE BELLVITGE E-08028 BARCELONA SPAIN UNIV BARCELONA,FAC BIOL,DEPT FISIOL IMMUNOL E-08028 BARCELONA SPAIN UNIV BARCELONA,FUNDACIO AUGUST PI I SUNYER E-08028 BARCELONA SPAIN
Titolo Testata:
Journal of leukocyte biology
fascicolo: 4, volume: 63, anno: 1998,
pagine: 405 - 417
SICI:
0741-5400(1998)63:4<405:TFTRMM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATING FACTOR-RECEPTOR; LEUKEMIA INHIBITORY FACTOR; HUMAN HEMATOPOIETIC-CELLS; LOOP-HELIX PROTEINS; DNA-BINDING MOTIF; C-MYB GENE; FACTOR PU.1; NF-M; MACROPHAGE DIFFERENTIATION; MYELOID DIFFERENTIATION;
Keywords:
PROLIFERATION; DEVELOPMENT; KNOCKOUT; GENE EXPRESSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
113
Recensione:
Indirizzi per estratti:
Citazione:
A.F. Valledor et al., "TRANSCRIPTION FACTORS THAT REGULATE MONOCYTE MACROPHAGE DIFFERENTIATION/", Journal of leukocyte biology, 63(4), 1998, pp. 405-417

Abstract

Although all the cells in an organism contain the same genetic information, differences in the cell phenotype arise from the expression of lineage-specific genes. During myelopoiesis, external differentiating signals regulate the expression of a set of transcription factors. Thecombined action of these transcription factors subsequently determines the expression of myeloid-specific genes and the generation of monocytes and macrophages, In particular, the transcription factor PU.1 hasa critical role in this process, We review the contribution of several transcription factors to the control of macrophage development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:54:40