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Titolo:
HISTOLOGICAL AND BEHAVIORAL PROTECTION BY (-)-NICOTINE AGAINST QUINOLINIC ACID-INDUCED NEURODEGENERATION IN THE HIPPOCAMPUS
Autore:
ONEILL AB; MORGAN SJ; BRIONI JD;
Indirizzi:
ABBOTT LABS,DEPT PATHOL,DIV PHARMACEUT PROD,BLDG AP10-LL 47C ABBOTT PK IL 60064 ABBOTT LABS,DEPT PATHOL,DIV PHARMACEUT PROD ABBOTT PK IL 60064
Titolo Testata:
Neurobiology of learning and memory
fascicolo: 1, volume: 69, anno: 1998,
pagine: 46 - 64
SICI:
1074-7427(1998)69:1<46:HABPB(>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; NICOTINE TREATMENT COUNTERACTS; NEUROLOGICAL DISEASE; NUCLEUS BASALIS; KYNURENIC ACID; LESIONED RATS; CELL-BODIES; NEURONS; SYSTEMS; DISAPPEARANCE;
Keywords:
HIPPOCAMPUS; LEARNING; MEMORY; NICOTINE; QUINOLINIC ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A.B. Oneill et al., "HISTOLOGICAL AND BEHAVIORAL PROTECTION BY (-)-NICOTINE AGAINST QUINOLINIC ACID-INDUCED NEURODEGENERATION IN THE HIPPOCAMPUS", Neurobiology of learning and memory, 69(1), 1998, pp. 46-64

Abstract

Injections of quinolinic acid (60, 180, and 600 nmol) in the dorsal hippocampus induced significant neurotoxicity that was evident 1 day after the injection. By day 3, pyramidal as well as granular cells were affected even at the lowest dose of quinolinic acid, an effect that persisted up to 20 days. Consistent with the histological findings, animals with bilateral injections in the dorsal hippocampus were cognitively impaired during acquisition and retention of spatial information inthe water maze. A subacute treatment with (-)-nicotine (62 mu mol/kg/day) delivered by subcutaneous minipumps prevented the histological and cognitive deficits induced by the bilateral quinolinic acid (60 nmol) injections. These data indicate that quinolinic acid can induce degeneration of both pyramidal as well as granule cells in the hippocampus, leading to cognitive impairments in the rat, and that activation of neuronal nicotinic acetylcholine receptors can prevent the neurodegenerative process induced by quinolinic acid. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:24:37