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Titolo:
BIOACTIVITY OF INTRADUODENALLY AND INTRAVENOUSLY INFUSED FRAGMENTS OFLUMINAL CHOLECYSTOKININ RELEASING-FACTOR (LCRF)
Autore:
SPANNAGEL AW; REEVE JR; GREELEY GH; YANAIHARA N; LIDDLE RA; GREEN GM;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,DEPT PHYSIOL SAN ANTONIO TX 78284 UNIV TEXAS,HLTH SCI CTR,DEPT PHYSIOL SAN ANTONIO TX 78284 UNIV CALIF LOS ANGELES,CTR DIGEST DIS,CURE LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,DEPT MED LOS ANGELES CA 00000 UNIV TEXAS,MED BRANCH,DEPT SURG GALVESTON TX 77555 YANAIHARA INST FUJINORNIYA JAPAN DUKE UNIV,MED CTR,DEPT MED DURHAM NC 27710
Titolo Testata:
Regulatory peptides
fascicolo: 3, volume: 73, anno: 1998,
pagine: 161 - 164
SICI:
0167-0115(1998)73:3<161:BOIAII>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT INTESTINAL SECRETION; BILE; ATROPINE; JUICE;
Keywords:
CCK; EXOCRINE PANCREAS; FEEDBACK REGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
A.W. Spannagel et al., "BIOACTIVITY OF INTRADUODENALLY AND INTRAVENOUSLY INFUSED FRAGMENTS OFLUMINAL CHOLECYSTOKININ RELEASING-FACTOR (LCRF)", Regulatory peptides, 73(3), 1998, pp. 161-164

Abstract

A luminal cholecystokinin releasing factor (LCRF), has been purified from intestinal secretion and found to have a mass of 8136 daltons. The amino-terminal 41 residues have been sequenced. Previous studies showed that intraduodenal infusion of the synthetic amino-terminal 35 amino acid peptide, LCRF1-35 significantly stimulated pancreatic protein and fluid secretion in conscious rats, but the peptide did not stimulate amylase release from isolated, dispersed pancreatic acini. In the present study, several fragments of LCRF were synthesized and tested for CCK-releasing activity (pancreatic protein secretion) to determine whether shorter fragments of LCRF exhibit the characteristic biologicalactivity of native LCRF and synthetic LCRF1-35. Compounds tested wereLCRF1-41, LCRF1-35, LCRF1-6, and LCRF11-25. Of the fragments shorter than LCRF1-35, only LCRF11-25 but not LCRF1-6 had significant CCK releasing activity. LCRF1-41 was equivalent to LCRF1-35 in potency and efficacy. Intravenous and intraduodenal infusion of LCRF1-35 elicited nearly identical dose-response curves. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:48:33