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Titolo:
TARGET PIONEERING AND EARLY MORPHOLOGY OF THE MURINE CHORDA TYMPANI
Autore:
SCOTT L; ATKINSON ME;
Indirizzi:
UNIV SHEFFIELD,DEPT BIOMED SCI,ALFRED DENNY BLDG,WESTERN BANK SHEFFIELD S10 2TN S YORKSHIRE ENGLAND UNIV SHEFFIELD,DEPT BIOMED SCI SHEFFIELD S10 2TN S YORKSHIRE ENGLAND
Titolo Testata:
Journal of Anatomy
, volume: 192, anno: 1998,
parte:, 1
pagine: 91 - 98
SICI:
0021-8782(1998)192:<91:TPAEMO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOCHONDRIAL ENZYME-ACTIVITY; TASTE-BUDS; POSTNATAL-DEVELOPMENT; DENDRITIC MORPHOLOGY; TRIGEMINAL GANGLION; NEUROTROPHIC FACTOR; NEURAL INDUCTION; RAT; PAPILLAE; TONGUE;
Keywords:
FACIAL NERVE; GUSTATORY PAPILLAE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
L. Scott e M.E. Atkinson, "TARGET PIONEERING AND EARLY MORPHOLOGY OF THE MURINE CHORDA TYMPANI", Journal of Anatomy, 192, 1998, pp. 91-98

Abstract

Many studies demonstrate that differentiation of certain sensory receptors during development is induced by their nerve supply. Thus the navigational accuracy of pioneering fibres to their targets is crucial to this process. The special gustatory elements of the facial and glossopharyngeal nerves are used extensively as model systems in this field. We examined the chorda tympani, the gustatory component of the facial nerve, to determine the precise time course of its development in mice. The transganglionic fluorescent tracer DiI was injected into the anterior aspect of the mandibular arch of fixed embryos aged between 30and 50 somites (E10-E12). It was allowed to diffuse retrogradely via the geniculate ganglion to the brainstem for 4 wk, before the distribution of DiI was determined using confocal laser scanning microscopy. Geniculate ganglion cells were first labelled at the 34 somite stage (E10). Pioneering chorda tympani fibres that arise from these cells passed peripherally and followed an oblique course as they grew towards the mandibular arch. At the 36 somite stage (E10.5), the peripheral component followed an intricate postspiracular course and passed anteriorly to arch over the primitive tympanic cavity, en route to the lingual epithelium. From the 36 to 50 somite stages (E10.5-E12), it consistently traced in the fashion of a 'U' bend. The central fascicle also traced at the 36 somite stage (E10.5) and just made contact with the brainstem. At the 40 somite stage (Ell), the central fibres clearly chose aroute of descent into the spinal trigeminal tract and branched into the solitary tract. Pioneering chorda tympani fibres contact the lingual epithelium when the target is primordial. The lingual epithelium maybe a source of a neurotropic factor that attracts peripheral chorda tympani fibres to the sites of putative papillae. However, the chorda tympani is probably not a vital influence on the subsequent differentiation of gustatory papillae, since the papillae are elaborated 5 d later at E15 in murine embryos. The early morphology of the nerve is true to the amniote vertebrate phenotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:54:59