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Titolo:
EFFECTS OF PROCAINAMIDE ON THE EXCITABLE GAP COMPOSITION IN COMMON HUMAN ATRIAL-FLUTTER
Autore:
JALIL E; LEFRANC P; LEBEAU R; MOLIN F; COSTI P; KUS T;
Indirizzi:
HOP SACRE COEUR,RES CTR,5400 W GOUIN BLVD MONTREAL PQ H4J 1C5 CANADA HOP SACRE COEUR,RES CTR MONTREAL PQ H4J 1C5 CANADA UNIV MONTREAL,DEPT PHARMACOL MONTREAL PQ H3C 3J7 CANADA
Titolo Testata:
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
fascicolo: 3, volume: 21, anno: 1998,
pagine: 528 - 535
SICI:
0147-8389(1998)21:3<528:EOPOTE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR-TACHYCARDIA; INTRAVENOUS IBUTILIDE; N-ACETYLPROCAINAMIDE; RESETTING RESPONSE; SINUS RHYTHM; FIBRILLATION; CONVERSION; STIMULATION; TERMINATION; CONDUCTION;
Keywords:
ATRIAL FLUTTER; PROCAINAMIDE; RESET-RESPONSE CURVE; EXCITABLE GAP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
E. Jalil et al., "EFFECTS OF PROCAINAMIDE ON THE EXCITABLE GAP COMPOSITION IN COMMON HUMAN ATRIAL-FLUTTER", PACE, 21(3), 1998, pp. 528-535

Abstract

The composition of the excitable gap (EG) in common atrial flutter (AFl) was determined before and during infusion of procainamide (PA) in 9 patients (6 men and 3 women; age 70 +/- 7 years). The EG rt as determined by introducing a premature stimulus after every 20th AFl complex-detected using a quadripolar electrode catheter placed just above thetricuspid valve. Diastole rr as scanned in 2- to 4-ms decrements to the atrial effective refractory period (ERP). The relationship between the coupling interval and the return cycle length (CL) determined a reset-response curve (RRC), which described the EG. PA (15 mg/kg) was administered during AFl over 30 minutes and RRC was repeated at maxim umAFl CL. PA prolonged AFl CL from 227 +/- 29 to 296 +/- 62 ms (P < 0.01) but did not terminate AFl. ERP during AFl prolonged from 169 +/- 24to 219 +/- 41 ms (P < 0.01). Control EG was 57 +/- 16 ms or 25% +/- 6% of AFl CL and on PA EG was 77 +/- 30 ms (P = 0.01), which was still 26% +/- 7% of the CL. Without drug, RRC was mixed in eight cases demonstrating an EG composed of fully excitable tissue (10 +/- 4 ms or 19% /- 10% of the EG) and partially refractory tissue (48 +/- 18 ms). PA did not change the duration of the fully excitable region (13 +/- 10 ms or 19% +/- 15% of EG). Peak PA plasma concentration was 47 +/- 20 mumol/L. PA prolonged AFl CL, ERP, and EG duration but did not change the proportion of AFl CL occupied by the EG. The persistance of fully excitable tissue at the head of the wavefront in the presence of PA maylargely explain its inefficacy in the acute termination of common AFl.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:58:14