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Titolo:
MECHANISMS REGULATING PROSTAGLANDIN-F2-ALPHA SECRETION FROM THE BOVINE ENDOMETRIUM
Autore:
TYSSELING KA; THATCHER WW; BAZER FW; HANSEN PJ; MIRANDO MA;
Indirizzi:
WASHINGTON STATE UNIV,DEPT ANIM SCI PULLMAN WA 99164 WASHINGTON STATE UNIV,DEPT ANIM SCI PULLMAN WA 99164 WASHINGTON STATE UNIV,CTR REPROD BIOL PULLMAN WA 99164 UNIV FLORIDA,DEPT DAIRY & POULTRY SCI GAINESVILLE FL 32611 TEXAS A&M UNIV,DEPT ANIM SCI COLLEGE STN TX 77843
Titolo Testata:
Journal of dairy science
fascicolo: 2, volume: 81, anno: 1998,
pagine: 382 - 389
SICI:
0022-0302(1998)81:2<382:MRPSFT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORPUS-LUTEUM REGRESSION; OXYTOCIN-INDUCED RELEASE; PROTEIN KINASE-C; ESTROUS-CYCLE; OVINE ENDOMETRIUM; PHOSPHOLIPASE-C; EARLY-PREGNANCY; PHOSPHOINOSITIDE HYDROLYSIS; PHORBOL ESTER; STIMULATION;
Keywords:
ENDOMETRIUM; OXYTOCIN; PROSTAGLANDIN F2-ALPHA; INOSITOL PHOSPHATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
K.A. Tysseling et al., "MECHANISMS REGULATING PROSTAGLANDIN-F2-ALPHA SECRETION FROM THE BOVINE ENDOMETRIUM", Journal of dairy science, 81(2), 1998, pp. 382-389

Abstract

The mechanism that regulates luteolytic PGF(2 alpha) secretion as stimulated by oxytocin is thought to involve induction of the inositol (1,4,5)-trisphosphate-diacylglycerol second messenger system, which mobilizes intracellular calcium and activates protein kinase C. In Experiment 1, endometrial explants taken from heifers on d 18.5 to 19.5 postestrus had increased PGF(2 alpha) secretion after treatment with 1 mu Mcalcium ionophore A23187 to increase intracellular calcium, 100 nM phorbol 12-myristate 13-acetate to activate protein kinase C, and 100 nMoxytocin. The stimulatory effects of oxytocin and calcium ionophore A23187 plus phorbol 12-myristate 13-acetate did not differ from each other. In Experiment 2, endometrial explants taken from cows on d 18.5 to 19.5 postestrus had increased PGF(2 alpha) secretion after treatmentwith 0.2 and 2 mu M thapsigargin to mobilize intracellular calcium that was sensitive to inositol (1,4,5)-trisphosphate. Secretion of PGF(2alpha) was also increased by 100 nM oxytocin and was influenced by the interaction of thapsigargin and oxytocin such that 100 nM oxytocin did not further increase the secretion of PGF(2 alpha) in the presence of 2 mu M thapsigargin. In Experiment 3, 100 nM oxytocin stimulated greater production of inositol trisphosphate and total inositol phosphates in the endometrium of cyclic cows than in the endometrium of pregnant cows on d 16.5 to 17.0 postestrus, although luteolysis was not yet initiated in the cyclic cows. These results are consistent with the hypothesis that the activation of the inositol (1,4,5)-trisphosphate-diacylglycerol second messenger system by oxytocin is involved in the stimulation of PGF(2 alpha) secretion from the endometrium during late diestrus in cows.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:24:25