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Titolo:
COMPARABLE ENGRAFTMENT KINETICS FOLLOWING PERIPHERAL-BLOOD STEM-CELL INFUSION MOBILIZED WITH GRANULOCYTE-COLONY-STIMULATING FACTOR WITH OR WITHOUT CYCLOPHOSPHAMIDE IN MULTIPLE-MYELOMA
Autore:
DESIKAN KR; BARLOGIE B; JAGANNATH S; VESOLE DH; SIEGEL D; FASSAS A; MUNSHI N; SINGHAL S; MEHTA J; TINDLE S; NELSON J; BRACY D; MATTOX S; TRICOT G;
Indirizzi:
UNIV ARKANSAS MED SCI,MYELOMA & TRANSPLANTAT RES CTR,4301 W MARKHAM,SLOT 508 LITTLE ROCK AR 72205 UNIV ARKANSAS MED SCI,ARKANSAS CANC RES CTR,DIV HEMATOL ONCOL LITTLE ROCK AR 72205
Titolo Testata:
Journal of clinical oncology
fascicolo: 4, volume: 16, anno: 1998,
pagine: 1547 - 1553
SICI:
0732-183X(1998)16:4<1547:CEKFPS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DOSE CYCLOPHOSPHAMIDE; BONE-MARROW TRANSPLANTATION; FACTOR G-CSF; PROGENITOR CELLS; CD34(+) CELLS; POSITIVE SELECTION; PLATELET RECOVERY; NORMAL VOLUNTEERS; RANDOMIZED TRIAL; CHEMOTHERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
K.R. Desikan et al., "COMPARABLE ENGRAFTMENT KINETICS FOLLOWING PERIPHERAL-BLOOD STEM-CELL INFUSION MOBILIZED WITH GRANULOCYTE-COLONY-STIMULATING FACTOR WITH OR WITHOUT CYCLOPHOSPHAMIDE IN MULTIPLE-MYELOMA", Journal of clinical oncology, 16(4), 1998, pp. 1547-1553

Abstract

Purpose: To compare, in the setting of tandem autotransplantations for multiple myeloma (MM), two established methods of peripheral-blood stem-cell (PBSC) procurement with chemotherapy or hematopoietic growth factor alone. Patients and Methods: Between June 1994 and July 1995, 44 patients with MM were randomized to PBSC mobilization with either granulocyte colony-stimulating factor (G-CSF) 16 mu g/kg (group 1; n = 22) or high-dose cyclophosphamide (HDCTX) 6 g/m(2) plus G-CSF 5 mu g/kg(group 2; n = 22). All 44 patients received melphalan 200 mg/m(2) with their first autograft and 32 patients proceeded to a second transplantation. Results: Group 2 required a significantly longer time interval for completion of PBSC collection than group 1 (median, 22 v 8 days;P = .0001), greater frequency of hospitalization (100% v 32%; P = .0001), and increased transfusion of platelets (86% v 18%; P = .0001) andpacked RBCs (86% v 55%; P = .02). Likewise, the incidence of fever and pneumonia/sepsis were higher in group 2 (P = .02 and P = .04, respectively). Surprisingly, despite greater CD34 cell quantities infused ingroup 2, median recovery times of granulocytes (both > 500/mu L and 2,500/mu L) and platelets (both > 50,000/mu L and > 100,000/mu L) were similar (all P > .7). Posttransplant toxicities were also similar. Conclusion: Compared with HDCTX plus G-CSF, high-dose G-CSF alone is associated with lower morbidity, shorter duration of PBSC mobilization, and comparable hematopoietic recovery after transplantation, which should result in significant cost reduction. Considering the relatively limited antitumor activity of HDCTX (10% with greater than or equal to 50% tumor cytoreduction), PBSC mobilization with HDCTX should be limitedto selected patients with persistent MM despite induction chemotherapy. (C) 1998 by American Society of Clinical Oncology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:40:02