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Titolo:
INHIBITION BY GINSENOSIDES RB-1 AND RG(1) OF METHAMPHETAMINE-INDUCED HYPERACTIVITY, CONDITIONED PLACE PREFERENCE AND POSTSYNAPTIC DOPAMINE-RECEPTOR SUPERSENSITIVITY IN MICE
Autore:
KIM HS; HONG YT; OH KW; SEONG YH; RHEU HM; CHO DH; OH S; PARK WK; JANG CG;
Indirizzi:
CHUNGBUK NATL UNIV,COLL PHARM CHEONGJU 361763 SOUTH KOREA CHUNGBUK NATL UNIV,DEPT PHARMACOL CHEONGJU 361763 SOUTH KOREA CHUNGBUK NATL UNIV,COLL VET MED CHEONGU 361763 SOUTH KOREA NATL INST TOXICOL RES SEOUL SOUTH KOREA KOREA RES INST CHEM TECHNOL TAEJON 305606 SOUTH KOREA UNIV MISSISSIPPI,MED CTR JACKSON MS 39216
Titolo Testata:
General pharmacology
fascicolo: 5, volume: 30, anno: 1998,
pagine: 783 - 789
SICI:
0306-3623(1998)30:5<783:IBGRAR>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; GINSENG TOTAL SAPONIN; REVERSE TOLERANCE; MOLECULAR MECHANISMS; BLOCKADE; RATS; SENSITIZATION; SENSITIVITY; ACCUMBENS; MK-801;
Keywords:
PANAX GINSENG; GINSENOSIDE; METHAMPHETAMINE; HYPERACTIVITY; CONDITIONED PLACE PREFERENCE; DOPAMINE RECEPTOR SUPERSENSITIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
H.S. Kim et al., "INHIBITION BY GINSENOSIDES RB-1 AND RG(1) OF METHAMPHETAMINE-INDUCED HYPERACTIVITY, CONDITIONED PLACE PREFERENCE AND POSTSYNAPTIC DOPAMINE-RECEPTOR SUPERSENSITIVITY IN MICE", General pharmacology, 30(5), 1998, pp. 783-789

Abstract

The ginsenosides Rb-1 and Rg(1), the major components of ginseng saponin, inhibited not only methamphetamine induced hyperactivity but alsoconditioned place preference (CPP) in mice following a single or repeated administration. Dopamine (DA) receptor supersensitivity, which developed in methamphetamine-induced CPP mice, was also inhibited by both Rb-1 and Rg(1). Therefore, the present results suggest that Rb-1 andRg(1) may be the active components of ginseng saponin in the modulation of methamphetamine-induced dopaminergic behaviors such as hyperactivity and CPP, supporting our previous conclusion that ginseng saponin might modulate methamphetamine-induced dysfunction at both the pre- and postsynaptic DA receptors. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:39:31