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Titolo:
ANALYSIS OF NUCLEAR DEGRADATION DURING LENS CELL-DIFFERENTIATION
Autore:
COUNIS MF; CHAUDUN E; ARRUTI C; OLIVER L; SANWAL M; COURTOIS Y; TORRIGLIA A;
Indirizzi:
ASSOC CLAUDE BERNARD,U450 INSERM,UNITE ASSOCIEE CNRS,29 RUE WILHEM F-75016 PARIS FRANCE FAC MED,LAB CULTIVO DE TEJIDOS MONTEVIDEO 11800 URUGUAY INST BIOL,INSERM U419 F-44035 NANTES 01 FRANCE UNIV WESTERN ONTARIO,DEPT BIOCHEM LONDON ON NGA 5C1 CANADA
Titolo Testata:
Cell death and differentiation
fascicolo: 4, volume: 5, anno: 1998,
pagine: 251 - 261
SICI:
1350-9047(1998)5:4<251:AONDDL>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOPTOTIC RAT THYMOCYTES; EMBRYONIC CHICK LENS; DNA-DEGRADATION; DEOXYRIBONUCLEASE-II; FIBER CELLS; MOUSE LENS; TERMINAL DIFFERENTIATION; ENDONUCLEASE ACTIVATION; ENDOGENOUS DNASE; EXPRESSION;
Keywords:
LENS CELLS; DIFFERENTIATION; NUCLEAR APOPTOSIS; GENOME CLEAVAGE; DNASES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
87
Recensione:
Indirizzi per estratti:
Citazione:
M.F. Counis et al., "ANALYSIS OF NUCLEAR DEGRADATION DURING LENS CELL-DIFFERENTIATION", Cell death and differentiation, 5(4), 1998, pp. 251-261

Abstract

Lens cells demonstrate a terminal differentiation process with loss of their organelles including nuclei. Chromatin disappearance is characterised by the same changes as most apoptotic cells, i.e. condensationof chromatin and cleavage into high molecular weight fragments and oligonucleosomes. The endo-deoxyribonucleases (bicationic (Ca2+, Mg2+), mono-cationic (Ca2+ or Mg2+) and acidic non-cationic dependent nucleases) are present in lens fibre cells. Our results suggest that the acidic non-cationic nuclease (DNase II) plays a major role in chromatin cleavage. This nuclease, known to be lysosomal, is found in lens fibre nuclei and only an antibody directed against DNase II inhibits the acidic DNA cleavage of lens fibre nuclei, In addition, there must be another DNase implicated in the process which is not DNase I but appears tobe a Ca2+, Mg2+ dependent molecule. Regulation of these DNase activities may be accomplished by the effect of post-translational modifications, acidic pH, mitochondrial release molecules, growth factors or oncogenes. Finally, fibre cells lose organelles without cytoplasmic elimination, The survival of these differentiated cells might be due to theaction of survival factors such as FGF 1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/06/20 alle ore 06:41:09