Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SELECTIVE OUTGROWTH AND DIFFERENTIAL TROPISM OF AMACRINE AND PHOTORECEPTOR AXONS TO CELL TARGETS DURING EARLY DEVELOPMENT IN-VITRO
Autore:
POLITI LE; INSUA F; BUZZI E;
Indirizzi:
CONSEJO NACL INVEST CIENT & TECN,INST INVEST BAHIA BLANCA,CC 857 RA-8000 BAHIA BLANCA BUENOS AIRES ARGENTINA UNIV NACL SUR RA-8000 BAHIA BLANCA BUENOS AIRES ARGENTINA
Titolo Testata:
Journal of neuroscience research
fascicolo: 1, volume: 52, anno: 1998,
pagine: 105 - 117
SICI:
0360-4012(1998)52:1<105:SOADTO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-2 S-LAMININ; ADHESION MOLECULES; NEURAL DEVELOPMENT; NEURITE GROWTH; SPINAL-CORD; C-ELEGANS; NEURONS; PROTEIN; FIBRONECTIN; GUIDANCE;
Keywords:
PHOTORECEPTORS; AMACRINE NEURONS; AXONAL GUIDANCE AND DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
L.E. Politi et al., "SELECTIVE OUTGROWTH AND DIFFERENTIAL TROPISM OF AMACRINE AND PHOTORECEPTOR AXONS TO CELL TARGETS DURING EARLY DEVELOPMENT IN-VITRO", Journal of neuroscience research, 52(1), 1998, pp. 105-117

Abstract

The axonal guidance and outgrowth in retinal neurons were investigated in cultures of pure retinal neurons (control) or in cocultures with heterologous BC3H-1 cells, Under control conditions, only about 10% ofretinal neurons developed axons; coculturing with BC3H-1 cells induced early axonal outgrowth and guidance to BC3H-1 cells in mast amacrineneurons, Both mechanisms were dependent on laminin and neural cell-adhesion molecules (N-CAMs) released by BC3H-1 cells, because they were prevented by antibodies directed against these molecules, The protein kinase C (PKC) inhibitor, staurosporine, reduced the effect of lamininon amacrine axonal outgrowth, suggesting that this effect was mediated by PKC, The occurrence of structures resembling synaptic boutons andthe expression of synaptophysin at the amacrine axon ends of heterologous connections suggested that amacrine axons establish true synapticcontacts rather than simply overlapping with the BC3H-1 cells, In contrast to the heterologous contacts with BC3H-1 cells, the amacrine-amacrine axonal contacts observed in the cocultures were independent of laminin and N-CAM., Axonal outgrowth occurred in about 10% of the photoreceptors and was not affected by BC3H-1 cells or by substratum pretreatment with laminin or N-CAM., These results show that different mechanisms affect axonal outgrowth and guidance in amacrine and photoreceptor neurons in vitro, and they suggest that similar mechanisms could contribute to the development of the scaffold of axon pathways in the retina in vivo. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:14:01