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Titolo:
THE STRUCTURAL BASIS OF MOLECULAR ADAPTATION
Autore:
GOLDING GB; DEAN AM;
Indirizzi:
FINCH UNIV HLTH SCI CHICAGO MED SCH,DEPT BIOL CHEM,3333 GREEN BAY RD N CHICAGO IL 60064 FINCH UNIV HLTH SCI CHICAGO MED SCH,DEPT BIOL CHEM N CHICAGO IL 60064 MCMASTER UNIV,DEPT BIOL HAMILTON ON CANADA
Titolo Testata:
Molecular biology and evolution
fascicolo: 4, volume: 15, anno: 1998,
pagine: 355 - 369
SICI:
0737-4038(1998)15:4<355:TSBOMA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALATE-DEHYDROGENASE; COLOR-VISION; ISOCITRATE DEHYDROGENASE; LACTATE-DEHYDROGENASE; ESCHERICHIA-COLI; SUBSTRATE-SPECIFICITY; COFACTOR SPECIFICITY; AMINO-ACID; EVOLUTION; HEMOGLOBIN;
Keywords:
MOLECULAR ADAPTATION; AMINO ACID REPLACEMENTS; PROTEIN STRUCTURE; PHYLOGENY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
G.B. Golding e A.M. Dean, "THE STRUCTURAL BASIS OF MOLECULAR ADAPTATION", Molecular biology and evolution, 15(4), 1998, pp. 355-369

Abstract

The study of molecular adaptation has long been fraught with difficulties, not the least of which is identifying out of hundreds of amino acid replacements those few directly responsible for major adaptations. Six studies are used to illustrate how phylogenies, site-directed mutagenesis, and a knowledge of protein structure combine to provide muchdeeper insights into the adaptive process than has hitherto been possible. Ancient genes can be reconstructed, and the phenotypes can be compared to modern proteins. Out of hundreds of amino acid replacements accumulated over billions of years those few responsible for discriminating between alternative substrates are identified. An amino acid replacement of modest effect at the molecular level causes a dramatic expansion in an ecological niche. These and other topics are creating theemerging field of ''paleomolecular biochemistry.''.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:27:01