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Titolo:
PRESYNAPTIC AND POSTSYNAPTIC LOCALIZATION OF GABA(B) RECEPTORS IN NEURONS OF THE RAT RETINA
Autore:
KOULEN P; MALITSCHEK B; KUHN R; BETTLER B; WASSLE H; BRANDSTATTER JH;
Indirizzi:
MAX PLANCK INST HIRNFORSCH,ABT NEUROANAT,DEUTSCHORDENSTR 46 D-60528 FRANKFURT GERMANY MAX PLANCK INST HIRNFORSCH,ABT NEUROANAT D-60528 FRANKFURT GERMANY NOVARTIS PHARMA INC CH-4002 BASEL SWITZERLAND
Titolo Testata:
European journal of neuroscience
fascicolo: 4, volume: 10, anno: 1998,
pagine: 1446 - 1456
SICI:
0953-816X(1998)10:4<1446:PAPLOG>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; CENTRAL-NERVOUS-SYSTEM; METABOTROPIC GLUTAMATE-RECEPTOR; TIGER SALAMANDER RETINA; MACAQUE MONKEY RETINA; INNER PLEXIFORM LAYER; ROD BIPOLAR CELLS; CAT RETINA; MAMMALIAN RETINA; RABBIT RETINA;
Keywords:
AMACRINE CELLS; GABA; GANGLION CELLS; HORIZONTAL CELLS; IMMUNOCYTOCHEMISTRY; METABOTROPIC RECEPTORS; RETINAL DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
P. Koulen et al., "PRESYNAPTIC AND POSTSYNAPTIC LOCALIZATION OF GABA(B) RECEPTORS IN NEURONS OF THE RAT RETINA", European journal of neuroscience, 10(4), 1998, pp. 1446-1456

Abstract

The recently cloned GABAB receptors were localized in rat retina using specific antisera. Immunolabelling was detected in the inner and outer plexiform layers (IPL, OPL), and in a number of cells in the inner nuclear layer and the ganglion cell layer. Double-labelling experiments for GABA (gamma-aminobutyric acid) and GABA(B) receptors, respectively, demonstrated a co-localization in horizontal cells and amacrine cells. Electron microscopy showed that GABA(B) receptors of the OPL werelocalized presynaptically in horizontal cell processes invaginating into photoreceptor terminals. In the IPL, GABA(B) receprors were present presynaptically in amacrine cells, as well as postsynaptically in amacrine and ganglion cells. The postnatal development of GABA(B) receptors was also studied, and immunoreactivity was observed well before morphological and synaptic differentiation of retinal neurons. The present results suggest a presynaptic (autoreceptor) as well as postsynaptic role for GABA(B) receptors. In addition, the extrasynaptic localization of GABA(B) receptors could indicate a paracrine function of GABA in the retina.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 18:41:34