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Titolo:
BIOLUMINESCENCE ASSAY OF ADENOSINE-TRIPHOSPHATE IN DRUG SUSCEPTIBILITY TESTING OF MYCOBACTERIUM-TUBERCULOSIS
Autore:
KUMAR V; SELVAKUMAR N; VENKATESAN P; CHANDRASEKARAN V; PARAMASIVAN CN; PRABHAKAR R;
Indirizzi:
TB RES CTR,ICMR CHENNAI 600031 INDIA
Titolo Testata:
INDIAN JOURNAL OF MEDICAL RESEARCH
, volume: 107, anno: 1998,
pagine: 75 - 77
SICI:
0971-5916(1998)107:<75:BAOAID>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Keywords:
ATP; BIOLUMINESCENCE ASSAY; MYCOBACTERIUM TUBERCULOSIS; SUSCEPTIBILITY TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
V. Kumar et al., "BIOLUMINESCENCE ASSAY OF ADENOSINE-TRIPHOSPHATE IN DRUG SUSCEPTIBILITY TESTING OF MYCOBACTERIUM-TUBERCULOSIS", INDIAN JOURNAL OF MEDICAL RESEARCH, 107, 1998, pp. 75-77

Abstract

Twenty three clinical isolates of M. tuberculosis and the reference strain, M. tuberculosis H37Rv were tested for their susceptibility to trifluoperazine (TFP) by the standard broth dilution method and the bioluminescence assay. The results showed that in 15 of the 23 isolates, the minimal inhibitory concentration (MIC) was identical in both the methods and in the remaining 8 isolates the difference in the MIC values between the methods, was less than two fold and was not significant. The findings suggest that the measurement of adenosine triphosphate (ATP) by bioluminescence assay can be employed as an alternative methodfor the rapid screening of clinical isolates for their susceptibilityto anti-mycobacterial agents.

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Documento generato il 02/12/20 alle ore 17:40:15